Westendorf et al., Mol Cell Biol 2002
:
Runx2 ( Cbfa1, AML-3 ) interacts with histone deacetylase 6 and represses the p21 ( CIP1/WAF1 ) promoter ... A carboxy-terminal repression domain distinct from the well characterized TLE/Groucho binding domain contributed to Runx2 mediated p21 repression
Vitolo et al., Cancer Biol Ther 2007
(Cell Transformation, Neoplastic) :
Overexpression of YAP65 prevented RUNX2 dependent downregulation of p21 ( CIP1 ) protein expression while promoting cell transformation
Hasegawa et al., Cancer Sci 2007
(Biliary Tract Neoplasms) :
Based on these results, RUNX3 is involved in TGF-beta induced expression of p21 and the resulting induction of TGF-beta dependent G ( 1 ) arrest