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CDKN1A — TXN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDKN1A — TXN (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: TXN — CDKN1A (physical association, two hybrid) Wang et al., Molecular systems biology 2011

Text-mined interactions from Literome

Ueno et al., J Biol Chem 1999 (Colonic Neoplasms) : Thioredoxin dependent redox regulation of p53 mediated p21 activation ... Luciferase assay revealed that transfection of TRX enhanced p53 dependent expression of p21 and further intensified Ref-1 mediated p53 activation
Yamada et al., Pulm Pharmacol Ther 2007 (Hyperoxia...) : TRX-1 had no effect on the protein and m-RNA levels of Bax and p21
Kuljaca et al., Carcinogenesis 2009 (Breast Neoplasms...) : Liquid chromatography/mass spectrometry analysis of the conditioned media revealed that p21 ( WAF1 ) knockdown significantly reduced secretion of thioredoxin (Trx) , a redox protein known to promote tumor angiogenesis ... Taken together, our data suggests that p21 ( WAF1 ) can induce Trx secretion and angiogenesis in cancer cells, by direct transcriptional repression of the TBP2 promoter