UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to JAK2

CSF2RA — JAK2

Pathways - manually collected, often from reviews:

KEGG Jak-STAT signaling pathway: CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR → JAK1/JAK2/JAK3/TYK2 (protein-protein, phosphorylation)
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → YWHAZ (YWHAZ) (modification, collaborate) Stomski et al., Blood 1999, Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
Stomski et al., Blood 1999, Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: YWHAZ (YWHAZ) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
Stomski et al., Blood 1999, Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
Lilly et al., Blood 2001, Hansen et al., Cell 2008, Brizzi et al., J Biol Chem 1994, Quelle et al., Mol Cell Biol 1994
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT5 (STAT5A/STAT5B) (modification, activates) Lilly et al., Blood 2001, Piu et al., Oncogene 2002, Hansen et al., Cell 2008, Okuda et al., Blood 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT5-active (STAT5A/STAT5B) (modification, activates)
Lilly et al., Blood 2001, Piu et al., Oncogene 2002, Hansen et al., Cell 2008, Okuda et al., Blood 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: None → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → None (modification, activates) Ramshaw et al., Blood 2007
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) (modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) (modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) (modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT1-3-active (STAT1/STAT3) (modification, activates)
Piu et al., Oncogene 2002, Brizzi et al., J Biol Chem 1996
Evidence: physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT1-3 (STAT1/STAT3) (modification, activates) Piu et al., Oncogene 2002, Brizzi et al., J Biol Chem 1996
Evidence: physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha complex (CSF2-CSF2RA) (modification, collaborate)
Sun et al., Blood 1999, Haman et al., J Biol Chem 1999 *, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Lilly et al., Blood 2001, McClure et al., Blood 2003 *, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008 *, Brizzi et al., J Biol Chem 1994, Woodcock et al., EMBO J 1994, Quelle et al., Mol Cell Biol 1994, Hercus et al., Blood 1994 *, Lock et al., Proc Natl Acad Sci U S A 1994 *, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2) (modification, collaborate)
Sun et al., Blood 1999, Haman et al., J Biol Chem 1999 *, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Lilly et al., Blood 2001, McClure et al., Blood 2003 *, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008 *, Brizzi et al., J Biol Chem 1994, Woodcock et al., EMBO J 1994, Quelle et al., Mol Cell Biol 1994, Hercus et al., Blood 1994 *, Lock et al., Proc Natl Acad Sci U S A 1994 *, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2) (modification, collaborate)
Sun et al., Blood 1999, Haman et al., J Biol Chem 1999 *, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Lilly et al., Blood 2001, McClure et al., Blood 2003 *, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008 *, Brizzi et al., J Biol Chem 1994, Woodcock et al., EMBO J 1994, Quelle et al., Mol Cell Biol 1994, Hercus et al., Blood 1994 *, Lock et al., Proc Natl Acad Sci U S A 1994 *, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: SHP2 (PTPN11) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
Evidence: physical interaction
NCI Pathway Database GMCSF-mediated signaling events: SHP2 (PTPN11) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA) (modification, collaborate)
Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
Evidence: physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA) (modification, collaborate)
Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
Evidence: physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: SHC (SHC1) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
Reactome Reaction: CSF2RA → JAK2 (reaction) Sakamaki et al., EMBO J 1992, Duronio et al., J Biol Chem 1992, Hayashida et al., Proc Natl Acad Sci U S A 1990 *, Kitamura et al., Cell 1991, Hansen et al., Cell 2008, Sorensen et al., J Biol Chem 1989, Quelle et al., Mol Cell Biol 1994, Feng et al., Mol Cell Biol 1997, Bone et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998
Reactome Reaction: CSF2RA → JAK2 (indirect_complex) Hayashida et al., Proc Natl Acad Sci U S A 1990 *, Kitamura et al., Cell 1991, Hansen et al., Cell 2008