Heibein et al., J Exp Med 2000
:
Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax
Davis et al., Cell Death Differ 2000
(Leukemia, Myeloid...) :
Overexpression of Bcl-2 resulted in inhibition of multiple parameters of apoptosis in response to purified perforin and granzyme B , including DNA fragmentation, changes in light scatter profile indicating cell shrinkage and increased refractivity, loss of mitochondrial membrane potential and inhibited colony formation in clonogenic assays