◀ Back to STAT1
CISH — STAT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shen et al., FEBS Lett 2000
:
Injection of IL-10 into mice activated STAT3 but not
STAT1 tyrosine phosphorylation and
induced suppressor of cytokine signal 2 (SOCS2), SOCS3, and
cytokine-inducible SH2 protein (CIS) mRNA expression in the liver ... These findings suggest that IL-10
inhibits IFN-alpha activated
STAT1 in the liver, at least in part, by inducing SOCS2, SOCS3, and
CIS expression, which may be responsible for the resistance of IFN-alpha therapy in patients who have high levels of IL-10 and recommends that IL-10 treatment for viral hepatitis should be cautious
O'Keefe et al., J Immunol 2001
:
Interestingly,
SOCS-1 inhibits the constitutive expression of
STAT-1alpha and its IFN-gamma induced tyrosine phosphorylation and binding to the GAS element in CIITA promoter IV
Imai et al., FEMS Immunol Med Microbiol 2003
:
We also observed that trehalose 6,6'-dimycolate/cord factor, a major component of the Mycobacterium tuberculosis cell wall, induces expression of
SOCS and
inhibits IFN-gamma stimulated phosphorylation of
STAT1 extensively in the cells
Jackson et al., J Immunol 2004
:
Taken together, these results suggest that cytokine induced maturation of DCs is under feedback regulation by SOCS proteins and that the switch from constitutive activation of the STAT6 pathway in iDCs to predominant use of STAT1 signals in mDC is mediated in part by
STAT1 induced
SOCS expression
Hwang et al., Mol Endocrinol 2004
(Carcinoma, Papillary...) :
RET/PTC induced
STAT1 transcriptional activation was not
inhibited by
suppressor of cytokine signaling-1 or -3, or protein inhibitors of activated STAT3 [ ( protein inhibitor of activated STAT ( PIAS3 ) ], but PIAS1 strongly repressed the RET/PTC induced transcriptional activity of STAT1
Zhao et al., J Infect 2007
(Respiratory Syncytial Virus Infections) :
These results suggest that RSV can
inhibit the phosphorylation of IFN-alpha-inducible
STAT1 and STAT2 by inducing the expression of
SOCS proteins in PMA treated U937 cells
Madonna et al., FASEB J 2008
:
Here we show that, after IFN-gamma stimulation,
SOCS1 inhibited IFN-gamma receptor and
STAT1 phosphorylation but maintained ERK1/2 activation
Hashimoto et al., Virology 2009
:
Furthermore, inhibition of SOCS1,
SOCS3 , or CIS activated type I IFN signaling by
inducing STAT1/2 phosphorylation
Guo et al., PloS one 2012
:
A novel viral
SOCS from infectious spleen and kidney necrosis virus : interacts with Jak1 and
inhibits IFN-a induced
Stat1/3 activation
Li et al., Immunity 2012
(Autoimmune Diseases...) :
We discovered that Egr2 and/or Egr3 directly induced expression of
suppressor of cytokine signaling-1 ( SOCS1 ) and SOCS3,
inhibitors of
STAT1 and STAT3, and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells