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INS — PARP1

Text-mined interactions from Literome

Spina Purrello et al., Mech Ageing Dev 2002 : In this investigation the effect of EGF, bFGF, IGF-I or INS on nuclear PARP and mitochondrial ADPRT activities were assessed in nuclei and mitochondria purified from developing ( 30 DIV ) or aging ( 90 and 190 DIV ) primary rat astrocyte cultures
Ye et al., Diabetes 2006 : The low-potency PARP inhibitors nicotinamide, 3-aminobenzamide, or PD128763 increased expression of a human insulin reporter gene suppressed by elevated glucose
Shibasaki et al., Proc Natl Acad Sci U S A 2007 : In addition, the small GTPase Rap1 , which is activated by cAMP specifically through Epac2 in pancreatic beta cells, mediates cAMP induced insulin secretion in a protein kinase A-independent manner
Horváth et al., Life Sci 2008 (Disease Models, Animal...) : The direct effect of insulin on the PARP activity of mononuclear leukocytes and human umbilical vein endothelial cells ( HUVEC ) in elevated glucose conditions was tested in vitro
Kelly et al., J Biol Chem 2010 (Diabetes Mellitus) : Activated Rap1A promotes glucose stimulated insulin secretion, islet cell hypertrophy, and islet cell proliferation, the latter exclusively through mammalian target of rapamycin complex 1, suggesting that Rap1 is an important regulator of beta-cell function
Okada et al., J Biol Chem 1997 : Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex