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EPO — PLCG1

Pathways - manually collected, often from reviews:

• BioCarta epo signaling pathway: EPO/EPO R/EPO R complex (EPOR-EPO) → PLC-gamma (PLCG1) (modification, activates)

Text-mined interactions from Literome

Ren et al., J Biol Chem 1994 : Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin dependent cell line
Marrero et al., Kidney Int 1998 : In hematopoietic cells, EPO induces tyrosine kinase ( TK ) -dependent activation of phospholipase C (PLC)-gamma 1 and Ca2+ influx via a voltage independent Ca2+ conductance ... Erythropoietin increased the tyrosine phosphorylation of PLC-gamma 1 , promoted membrane complex formation between PLC-gamma 1 and the EPO receptor itself, and raised the levels of intracellular inositol 1,4,5-trisphosphate and intracellular Ca2+