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EPO — SHH

Text-mined interactions from Literome

Ueda et al., J Clin Invest 2010 (Myocardial Infarction...) : Erythropoietin also increased the expression of sonic hedgehog in cardiomyocytes, and inhibition of sonic hedgehog signaling suppressed the erythropoietin induced increase in angiogenic cytokine expression
Wu et al., Neurobiol Dis 2010 : Because carbamylated erythropoietin (EPO) may induce SHH , we investigated whether BDNF dependent SHH expression and 3-NP resistance require prior induction of EPO ... Recombinant rat EPO ( rEPO ) induced SHH and attenuated 3-NP neurotoxicity ... Overall, our results demonstrate that BDNF dependent SHH expression and 3-NP resistance require prior induction of EPO , thus establishing a signaling cascade of `` BDNF -- > EPO -- > SHH -- > 3-NP resistance '' in rat cortical neurons