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FAS — PRKAB1
Text-mined interactions from Literome
Zhou et al., Cancer Res 2007
(Ovarian Neoplasms) :
This indicates that substrate accumulation from
FAS inhibition triggering
AMPK activation, not end-product depletion of fatty acids, is likely responsible for AMPK activation ... Thus, pharmacologic
FAS inhibition selectively
activates AMPK in ovarian cancer cells, inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation
An et al., J Biol Chem 2007
:
Notably,
AMPK activation
increased threonine phosphorylation of
FAS , and this effect was blocked by adenovirus encoding dominant negative AMPK ... Finally,
AMPK dependent
FAS phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes
Jung et al., Exp Cell Res 2009
(Carcinoma) :
In the present study, we demonstrate that
Fas signaling in DU145 human prostate cancer cells
leads to rapid activation of
AMP activated protein kinase (AMPK) , which plays a major role in adaptive responses to ATP depleting conditions ; prostate cancer is resistant to Fas mediated apoptosis despite high levels of Fas surface expression and no mutation in the Fas gene
Lu et al., J Pathol 2010
(Neurodegenerative Diseases) :
Moreover,
AMPK activation significantly increased 3-hydroxy-3-methylglutaryl-coenzyme A ( HMG-CoA) reductase and acetyl-CoA carboxylase (ACC) phosphorylation and
reduced fatty acid synthase (FAS) expression in the brains of high-cholesterol fed old mice, which reduced cholesterol levels, down-regulated cholesterol 24-hydroxylase ( CYP46A1 ) and beta-amyloid converting enzyme 1 (BACE1) expression, decreased eukaryotic translation initiation factor 2alpha ( eIF2alpha ) phosphorylation, and lowered Abeta deposits
Pil Hwang et al., Mol Nutr Food Res 2013
:
These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and
FAS through LKB1/SIRT1 and
AMPK activation in HepG2 cells, suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation