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BCL2 — EIF2AK2
Text-mined interactions from Literome
Ruvolo et al., J Biol Chem 2008
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
PKR regulates B56 ( alpha ) -mediated
BCL2 phosphatase activity in acute lymphoblastic leukemia derived REH cells ... Suppression of
PKR promoted
BCL2 phosphorylation with concomitant loss of B56alpha phosphorylation at serine 28 and inhibition of mitochondrial PP2A activity
Yang et al., Cell Res 2009
:
Repression of
PKR mediates palmitate
induced apoptosis in HepG2 cells through regulation of
Bcl-2 ... The decrease in the phosphorylation of
Bcl-2 at Ser70 upon exposure to palmitate is
mediated by inhibition of
PKR and possibly by c-Jun N-terminal kinase (JNK), whereas the phosphorylation of Bcl-2 at Ser87 is unaffected by palmitate or PKR
Cheng et al., Blood cancer journal 2013
:
Thus, inhibition of
PKR activity
leads to hyperphosphorylation of
Bcl-2 , stabilization of Bcl-2/Bax interaction and decreased Bax insertion into the outer mitochondrial membrane