Utsugi et al., Eur J Pharmacol 2002
:
Furthermore, mitogen activated protein kinase kinase ( MEK)-1-specific inhibitor, 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ), blocked the lipopolysaccharide induced p44/42 ERK activation and PDGF production
Clark et al., J Biol Chem 1997
(Cell Transformation, Neoplastic) :
We observed that a dominant negative mutant of SEK1/JNKK , an activator of JNKs, selectively inhibited oncogenic Ras activation of JNK and Ras transformation, but not Ras activation of the p42 mitogen activated protein kinase