Gene interactions and pathways from curated databases and text-mining

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CSK — IL6

Text-mined interactions from Literome

Davey et al., Microvasc Res 2006 : Endothelial cells from choroid demonstrated enhanced release of IL-6 in response to MDP, and synergy was observed following treatment with MDP and either Pam3CSK4 or LPS
Rydberg et al., Immunology 2009 (Carcinoma, Squamous Cell...) : Poly ( I:C ) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam ( 3 ) CSK ( 4 ) increased viability
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 modestly attenuated the expression of IL6 and IL8 induced by the TLR2/TLR1 ligand Pam ( 3 ) CSK ( 4 ), but did not affect the expression induced by the TLR2/TLR6 ligand MALP-2
Ultaigh et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid) : OPN301 significantly decreased Pam3CSK4 induced cytokine production of tumour necrosis factor alpha ( TNF-a ), IL-1ß, IL-6 , interferon ( IFN ) -? and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures ( all P < 0.05 )
Caraş et al., Roum Arch Microbiol Immunol 2011 : Unexpectedly, treatment with anti-LR2 blocking antibody inhibited only IL-6 production induced by Pam3CSK4 while the level of TNF-alpha was unchanged
Li et al., Inflammation 2012 (Endotoxemia) : We found that in vitro LPS and Pam3CSK4 induced TNF-a, and IL-6 production are decreased in macrophages from GS/GS mice compared with WT mice ( p? < ?0.05 )
Morandini et al., J Periodontol 2013 (Inflammation) : Knockdown of TLR2 decreased IL-6 and IL-8 in response to P. gingivalis LPS, or Pam2CSK4 and Pam3CSK4, in a similar manner in both fibroblasts subpopulations
Yao et al., Eur J Immunol 2012 (Inflammation) : Here, we report that ATP enhanced murine IEC production of KC, IL-6 , TGF-ß, and thymic stromal lymphopoietin in response to TLR1/2 stimulation by Pam ( 3 ) CSK ( 4 ) ( PAM )
Lee et al., Arterioscler Thromb Vasc Biol 2012 (Atherosclerosis) : Moreover, cAMP response element binding protein small interfering RNA inhibited pam3CSK4 induced IL-6 production and VSMC migration ... Additionally, Rac1 small interfering RNA inhibited pam3CSK4 induced VSMC migration but not IL-6 production