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FAS — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK) → SYK (SYK) (modification, collaborate) Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK) → Src (SRC) (modification, collaborate) Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: Src (SRC) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK) → PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1) (modification, activates)
  Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: Complex of SRC-FAS-LCK (anti bait coimmunoprecipitation) Akimzhanov et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: Complex of FAS-LCK-SRC-PLCG1 (anti bait coimmunoprecipitation) Akimzhanov et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: SRC — FAS (physical association, anti bait coimmunoprecipitation) Akimzhanov et al., Proc Natl Acad Sci U S A 2010*
• IRef Intact Interaction: SRC — FAS (physical association, anti bait coimmunoprecipitation) Kleber et al., Cancer Cell 2008*

Text-mined interactions from Literome

Li et al., Mol Cell Biol 2003 : Consistent with the ability of CrkL to biochemically associate with Cas, we found that Src triggers translocation of CrkL to focal adhesions (FAs) in a manner dependent on Cas
Reinehr et al., Gastroenterology 2008 (Disease Models, Animal...) : In quiescent HSCs, CD95L led to a rapid phosphorylation of the epidermal growth factor receptor (EGFR), extracellular signal regulated kinase ( Erk ), and c-Src , but not of c-Jun-N-terminal kinase and p47(phox), an activating subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase