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SHC1 — VEGFA

Text-mined interactions from Literome

Saucier et al., Proc Natl Acad Sci U S A 2004 (Neoplasms...) : The importance of Shc recruitment to RTKs for the induction of VEGF was further demonstrated by using mutants of the Neu/ErbB2 RTK, where the Shc , but not Grb2, binding mutant induced VEGF ... Moreover, the use of fibroblasts derived from ShcA-deficient mouse embryos, demonstrated that Shc was essential for the induction of VEGF by the Met/hepatocyte growth factor RTK oncoprotein and by serum derived growth factors
Oshikawa et al., Am J Physiol Heart Circ Physiol 2012 (MAP Kinase Signaling System) : Novel role of p66Shc in ROS dependent VEGF signaling and angiogenesis in endothelial cells ... However, a role of p66Shc in VEGF signaling and physiological responses in ECs is unknown ... Here we show that VEGF promotes p66Shc phosphorylation at Ser36 through the JNK/ERK or PKC pathway as well as Rac1 binding to a nonphosphorylated form of p66Shc in ECs