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EGF — FOXO3
Text-mined interactions from Literome
Li et al., Biochem Pharmacol 2010
:
Simultaneously, they suppressed
EGF induced decreases of
FOXO3a nucleus accumulation and p27 ( Kip1 ) mRNA expression
Qi et al., BMC cancer 2011
(Colonic Neoplasms) :
Genistein inhibits proliferation of colon cancer cells by attenuating a negative
effect of
epidermal growth factor on tumor suppressor
FOXO3 activity ... The aim of this study was to assess if genistein exerts anti-proliferative properties by attenuating the negative
effect of
EGF on
FOXO3 activity ... The effect of genistein on proliferation stimulated by
EGF mediated loss of
FOXO3 was examined in human colonic cancer HT-29 cells ...
EGF induced
FOXO3 phosphorylation and translocation were assessed in the presence of genistein ...
EGF mediated loss of
FOXO3 interactions with p53 ( co-immunoprecipitation ) and promoter of p27kip1 ( ChIP assay ) were examined in presence of genistein in cells with mutated p53 ( HT-29 ) and wild type p53 ( HCT116 ) ... Upstream of FOXO3, genistein acts via the PI3K/Akt pathway to inhibit
EGF stimulated
FOXO3 phosphorylation ( i.e. favors active state )
Saxena et al., Antioxid Redox Signal 2013
(Colonic Neoplasms...) :
Inhibition of AR also prevented the
epidermal growth factor induced phosphorylation of phosphatidylinositol 3-kinase (PI3K), serine/threonine kinase ( AKT ), c-Jun, c-Fos, PTEN, and
FOXO3a , and deoxyribonucleic acid ( DNA ) -binding activity of AP-1