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IL1A — PPARA

Text-mined interactions from Literome

Sacks et al., Diabetes Care 2011 (Coronary Artery Disease...) : Pioglitazone therapy in type 2 diabetes was associated with decreased expression of IL-1ß , IL-1Ra, and IL-10 in EAT ; decreased IL-10 in SAT ; and increased PPAR? in SAT
Nebbaki et al., Arthritis Res Ther 2012 (Osteoarthritis) : In this study, our objective was to define the roles of Egr-1 and Sp1 in IL-1 mediated down-regulation of PPAR? expression ... Overexpression of Egr-1 potentiated, whereas overexpression of Sp1 alleviated, the suppressive effect of IL-1 on the PPAR? promoter, suggesting that Egr-1 may mediate the suppressive effect of IL-1 ... Consistently, Egr-1 silencing prevented IL-1 mediated down-regulation of PPAR? expression ... Our results indicate that induction and recruitment of Egr-1 contributed to the suppressive effect of IL-1 on PPAR? expression