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PREX1 — RAC2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Dinauer et al., Curr Opin Hematol 2003
:
Rac activation in response to neutrophil chemoattractants may be
regulated in large part by a newly identified guanine nucleotide exchange factor,
P-Rex1 , which is activated by either phosphatidylinositols or Gbetagamma subunits
Dong et al., Curr Biol 2005
:
We generated a mouse line in which the P-Rex1 gene is disrupted and found that
P-Rex1 deficiency did not significantly affect Rac1 activation but
diminished Rac2 activation in response to a chemoattractant fMLP in mouse neutrophils
Qin et al., Oncogene 2009
(Lymphatic Metastasis...) :
Silencing endogenous
P-Rex1 in metastatic prostate cancer PC-3 cells selectively
inhibited Rac activity and reduced cell migration and invasion in response to ligands of both epidermal growth factor receptor and G-protein coupled CXC chemokine receptor 4 ... Thus, by functioning as a coincidence detector of chemotactic signals from both GPCRs and RTKs,
P-Rex1 dependent activation of
Rac promotes prostate cancer metastasis
Naikawadi et al., Circ Res 2012
:
TNF-a stimulated
Rac activation and reactive oxygen species production in a
P-Rex1 dependent manner