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IRAK1 — TLR2
Pathways - manually collected, often from reviews:
-
BioCarta toll-like receptor pathway:
TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1)
→
TRAF6
(modification, activates)
-
BioCarta toll-like receptor pathway:
TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2)
→
TRAF6
(modification, activates)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1)
→
TLR2/TLR6/MYD88/IRAK complex (IRAK1-MYD88-TLR6-TLR2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR2/TLR2/MYD88/IRAK complex (MYD88-IRAK1-TLR2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2)
→
TLR2/TLR2/MYD88/IRAK complex (MYD88-IRAK1-TLR2)
(modification, collaborate)
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
Reactome Reaction:
TLR2
→
IRAK1
(indirect_complex)
Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Rao et al., Mol Cell Biol 2005, Keating et al., J Biol Chem 2007, Gottipati et al., Cell Signal 2008, Wan et al., J Biol Chem 2009, Lin et al., Nature 2010, Flannery et al., J Biol Chem 2011
-
Reactome Reaction:
TLR2
→
IRAK1
(reaction)
Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Rao et al., Mol Cell Biol 2005, Keating et al., J Biol Chem 2007, Gottipati et al., Cell Signal 2008, Wan et al., J Biol Chem 2009, Lin et al., Nature 2010, Flannery et al., J Biol Chem 2011
-
WikiPathways ApoE and miR-146 in inflammation and atherosclerosis:
TLR2
→
IRAK1/TRAF4
(mim-binding)
-
WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway:
TLR1/TLR2/TLR4/TLR5/TLR6/TLR7/TLR8/TLR9/TLR10/IL1A
→
Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Jacinto et al., J Immunol 2002
:
Correspondingly, stimulation of
TLR2 by LTA, although activating IRAK, does not
cause IRAK degradation
Kobayashi et al., Cell 2002
(Salmonella Infections) :
Thus,
IRAK-M regulates
TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003
:
PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting
TLR induced
IRAK activation
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88,
IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Kubo-Murai et al., J Biochem 2008
:
Stimulation of these cells with
TLR ligands did not
cause the degradation of
IRAK-1 , which was clearly observed in the parent cells
Kawagoe et al., Nat Immunol 2008
:
Thus, IRAK2 is critical in late-phase
TLR responses , and
IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation
Ahmad et al., Blood 2008
:
Altogether, these results unequivocally show that HSV-1 induces
TLR2 dependent activation of IL-15 gene expression, which requires the recruitment of both MyD88 and TIRAP/Mal and the activation of
IRAK1 and TRAF6 leading to NF-kappaB translocation to the nucleus
Nguyen et al., Cell Signal 2009
:
Phosphorylation of
IRAK-1 by IRAK-4 in
response to
TLR activation may then release IRAK-1 from the inhibitory constraint exerted by its C-terminal domain
Cho et al., J Cell Physiol 2010
(Calcinosis) :
Overexpression of miR-146a induced the inhibition of
IRAK1 expression and inhibited basal and TNF-alpha- and
TLR ligand
induced osteogenic differentiation
Kar et al., Eur J Immunol 2011
(Inflammation...) :
Analysis of upstream signaling events revealed that
TLR 2/4 mediated MyD88 dependent participation of IL-1R activated kinase
(IRAK)1 , TNF receptor associated factor (TRAF)6 and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages
Kumar Pachathundikandi et al., PloS one 2011
(Helicobacter Infections) :
Using phospho-specific antibodies and luciferase reporter assays, we further demonstrate that H. pylori induces
IRAK-1 and I?B phosphorylation in a
TLR dependent manner, and this was required for activation of transcription factor NF-?B
Liu et al., J Immunol 2012
:
Because IRAK1 is required for TLR7/9 induced IFN-I production, we propose that
TLR2 signaling
induces rapid depletion of
IRAK1 , which impairs IFN-I induction by TLR7/9
Unger et al., PLoS Pathog 2012
(Haemophilus Infections...) :
Rhinovirus attenuates non-typeable Hemophilus influenzae stimulated IL-8 responses via
TLR2 dependent degradation of
IRAK-1