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IRF6 — SRC
Text-mined interactions from Literome
Napolitani et al., Eur J Immunol 2003
:
We show that
LPS induces activation of
c-Src and Lyn in human DC
Severgnini et al., Am J Physiol Lung Cell Mol Physiol 2004
(Acute Disease...) :
We also demonstrated that
LPS activates both the STAT kinases,
Src and JAK, in the lung with kinetics that are consistent with STAT activation
Leu et al., Mol Immunol 2006
(Endotoxemia...) :
And this
LPS mediated
c-Src induction is also observed in macrophages recovered from LPS challenged rats
Hsu et al., Mol Pharmacol 2007
:
In essence, GA decreased
LPS induced
Hsp90/pp60Src heterocomplex formation
Su et al., Clin Chim Acta 2006
:
Src , Lyn and MAPKs are
involved in LTA and
LPS signaling in murine macrophages
Lee et al., J Immunol 2007
(Respiratory Distress Syndrome, Adult) :
LPS resulted in
c-Src phosphorylation in lung tissue and the phospho-c-Src was predominantly localized in recruited neutrophils and alveolar macrophages
Lin et al., Toxicol Appl Pharmacol 2008
:
LPS stimulated
Src , PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110
Lee et al., Br J Pharmacol 2008
(Disease Models, Animal...) :
In particular, davallialactone strongly inhibited the
LPS induced phosphorylation and kinase activity of
Src , implying that Src may be a potential pharmacological target of davallialactone
Liu et al., J Biol Chem 2012
:
LPS increased binding of both
c-Src and Fyn to GST-TRAF6 but not to a GST-TRAF6 mutant in which the three prolines in the putative Src homology 3 domain binding motif ( amino acids 461-469 ) were substituted with alanines ... Finally,
LPS increased binding of activated Tyr ( P ) ( 416 ) -SFK to GST-TRAF6, and preincubation of HMVEC-Ls with SFK-selective tyrosine kinase inhibitors, PP2 and SU6656,
diminished TRAF6 binding to
c-Src and Fyn
McElroy et al., PloS one 2012
:
LPS induction of COX-2
requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease ( MMP ) activity
Lee et al., Cell communication and signaling : CCS 2012
:
We observed that
LPS induced TLR4, MyD88,
c-Src , and p47phox complex formation determined by co-immunoprecipitation and Western blot