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TLR4 — VIP

Text-mined interactions from Literome

Gutiérrez-Cañas et al., Rheumatology (Oxford) 2006 (Arthritis, Rheumatoid...) : The effects of VIP on basal or TNF-alpha or lipopolysaccharide (LPS) induced TLR2, TLR4 and MyD88 expression and its effects on TLR4 mediated CCL2 and CXCL8 chemokine production were studied by reverse transcription-polymerase chain reaction, western blotting and enzyme linked immunosorbent assay ... VIP down-regulated the induced but not the constitutive expression of TLR4 and MyD88 in RA FLS
Arranz et al., Ann N Y Acad Sci 2006 (Colitis...) : Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS induced colitis
Foster et al., J Leukoc Biol 2007 : Pivotal advance : vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages ... VIP inhibited up-regulation of TLR4 expression in THP1 cells in response to LPS from Escherichia coli or the periodontal pathogen Porphyromonas gingivalis within 6 h poststimulation but had less of an effect on TLR2 ... VIP decreased monocyte differentiation to macrophages induced by LPS from either species and also reduced overall TLR2 and TLR4 expression in these cells
Arranz et al., Mol Immunol 2008 : In the present report we demonstrate that VIP directly suppressed TLR4 expression on naïve primary mouse macrophages utilizing signalling cascades that control TLR4 transcription ... VIP induced suppression of TLR4 occurred at the transcriptional level by decreasing PU.1 DNA binding ... Mutation of the proximal PU.1 but not the AP-1 binding site on the TLR4 promoter abrogated VIP induced suppression of TLR4 transcription
Zuo et al., Zhonghua Er Ke Za Zhi 2010 (Acute Lung Injury) : [ Effects of vasoactive intestinal peptide on Toll-like receptor (TLR) 2 mRNA and TLR4 mRNA expression on acute lung injury induced by lipopolysaccharide in rat ]