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MYC — RELA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nakai et al., J Neurochem 2000
:
The present results provide additional support for the view that
NF-kappaB activation
contributes to
c-Myc and p53 induction and subsequent apoptosis in an excitotoxic model of Huntington 's disease
Kim et al., Carcinogenesis 2000
(Cell Transformation, Neoplastic...) :
Ectopic expression of the transactivating p65 subunit of
NF-kappaB in MCF-10F cells
induced the c-myc oncogene promoter, which is driven by two NF-kappaB elements, and endogenous
c-Myc levels
Soriani et al., Infect Immun 2001
:
Myc activation was also associated with an increase of IkappaBalpha turnover, suggesting that elevated
Myc expression may be
dependent on
NF-kappaB
Bhat-Nakshatri et al., Oncogene 2002
(Breast Neoplasms) :
Using breast cancer cell lines derived from transgenic mice that overexpress specific oncogene/growth factors in the mammary gland, we show that heregulin but not her2/neu,
c-Myc or v-Ha-ras
plays a major role in constitutive
NF-kappaB activation ... Her2/neu potentiated tumor necrosis factor alpha (TNFalpha)-inducible NF-kappaB activation whereas
c-Myc potentiated 12-o-tetracecanyolphorbol-13-acetate ( TPA ) -induced
NF-kappaB activation
Chapman et al., Biochem J 2002
(Neoplasms) :
Furthermore,
NF-kappaB can
induce c-Myc gene expression, suggesting that the activities of these factors are functionally linked
Park et al., J Biol Chem 2003
:
In light of findings that
NF-kappa B stimulates
Myc oncoprotein expression in cancers, our findings suggest that NO should be investigated as a prospective therapeutic cancer agent
Matsumura et al., Cell cycle (Georgetown, Tex.) 2003
:
c-Myc and E2F1
inhibit NF-kappaB activities induced by TNFalpha or reactive oxygen species
Keller et al., Oncogene 2005
(Burkitt Lymphoma) :
Interestingly, Emu-Myc B cells express reduced levels of cytoplasmic and nuclear NF-kappaB 1 and have reduced Rel/NF-kappaB DNA binding activity, suggesting that
Myc mediated repression of
NF-kappaB 1 might mediate its proliferative and apoptotic effects on B cells
Yao et al., Oral Dis 2007
(Tongue Neoplasms) :
Furthermore, L-685,458 down-regulated cyclin D1, B-cell lymphocytic-leukemia proto-oncogene 2 and
c-Myc expressions, which are
regulated by the transcription factor
NF-kappaB