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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to EIF4G3
EIF4A1 — EIF4G3
Pathways - manually collected, often from reviews:
BioCarta internal ribosome entry pathway :
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
→
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
(translational initiation, activates)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, activates)
BioCarta internal ribosome entry pathway :
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, activates)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta eukaryotic protein translation :
40s Ribosome subunit/RNA strand complex ()
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
eIF3 (EIF3S10)
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
eIF1 (EIF1)
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, activates)
BioCarta eukaryotic protein translation :
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
→
EIF-2 complex (EIF2S1-EIF2S2-EIF2S3)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
PTB (PTBP1/PTBP2)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF3 (EIF3S10)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
→
EIF-4E (EIF4E)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
→
EIF-4A (EIF4A1)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
→
eIF-4G (dimer) complex (EIF4G1-EIF4G2-EIF4G3)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
EIF-4A (EIF4A1)
→
eIF-4G (dimer) complex (EIF4G1-EIF4G2-EIF4G3)
(modification, collaborate)
BioCarta eukaryotic protein translation :
43s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3)
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
43s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3)
→
eIF4F/mRNA complex (EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
→
eIF4F/mRNA complex (EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
KEGG RNA transport :
EIF4G1/EIF4G2/EIF4G3
→
EIF4A1/EIF4A2
(protein-protein, binding/association)
Reactome Reaction :
EIF4A1
→
EIF4G3
(direct_complex)
Okumura et al., Genes Dev 2007
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
IRef Biogrid Interaction :
EIF4A1
—
EIF4G3
(colocalization, biochemical)
Havugimana et al., Cell 2012
IRef Biogrid Interaction :
EIF4A1
—
EIF4G3
(physical association, affinity chromatography technology)
Ewing et al., Molecular systems biology 2007
IRef Hprd Interaction :
EIF4G3
—
EIF4A1
(in vitro)
Gradi et al., Mol Cell Biol 1998 *
IRef Hprd Interaction :
EIF4G3
—
EIF4A1
(in vivo)
Gradi et al., Mol Cell Biol 1998 *
IRef Intact Interaction :
EIF4G3
—
EIF4A1
(physical association, anti bait coimmunoprecipitation)
Ewing et al., Molecular systems biology 2007
IRef Intact Interaction :
Complex of 57 proteins
(association, anti tag coimmunoprecipitation)
Jourdan et al., Proteomics 2012
STRING interaction :
EIF4G3
—
EIF4A1
(interaction, mapped from grid reactome kegg_pathways mint intact dip)
STRING interaction :
EIF4A1
—
EIF4G3
(interaction, mapped from grid reactome kegg_pathways mint intact dip)