◀ Back to MAPK1

CDK4 — MAPK1

Pathways - manually collected, often from reviews:

• KEGG Melanoma: MAPK1/MAPK3 → CDK4 (gene expression, expression)
• WikiPathways Signaling Pathways in Glioblastoma: MAPK1/MAPK3 → Complex of CCND1-CCND2-CDK4 (mim-stimulation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK1 — CDK4 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013

Text-mined interactions from Literome

Liu et al., Di Yi Jun Yi Da Xue Xue Bao 2002 (Cardiomyopathy, Hypertrophic...) : [ Regulation of cyclin dependent kinase inhibitors by mitogen activated protein kinase in angiotensin II-stimulated vascular smooth muscle cell hypertrophy ] ... To investigate the role of mitogen activated protein kinase ( MAPK ) in the regulation of cyclin dependent kinase inhibitors ( CDKI ) in the process of vascular smooth muscle cell ( VSMC ) hypertrophy induced by angiotensin II stimulation
Yang et al., Biol Reprod 2004 : FSH activation of CDK4 was mediated by cAMP and ERK-1/2
Lee et al., J Cell Biochem 2006 : In addition, PD 98059 ( a MEK inhibitor ), SB 203580 ( a p38 MAPK inhibitor ), and SP 600125 ( a JNK inhibitor ) blocked the EGF induced stimulation of [ 3H ] -thymidine incorporation and CDK-2/4 expression
Benson et al., Blood 2009 (MAP Kinase Signaling System) : The effect results at least in part via enhanced MAPK mediated modulation of p27 and CDK4