◀ Back to MAPK1

MAP3K8 — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → MAP3K8 (increases, MAP3K8 Activity, MAPK1 Activity) Channavajhala et al., J Biol Chem 2003*
  Evidence: Cot expression has been shown to induce ERK and JNK activation
• OpenBEL Selventa BEL large corpus: MAPK1 → MAP3K8 (increases, MAP3K8 Activity, MAPK1 Activity)
  Evidence: MyD88 also interacts directly with AKT, and a dominant-negative mutant of AKT causes a defect in MyD88-dependent NF-kB transcriptional activity. However, the binding of NF-kB to DNA is not affected by inhibiting AKT, indicating that AKT might be involved in the phosphorylation of the p65 transactivation domain. A dominant-negative mutant of MyD88 was shown to block the kinase activity of AKT generated in response to LPS and IL-1, and a dominant-negative mutant of p85 inhibited the NF-kB activity...
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): MAP3K8 → MAPK3/MAPK1 (activation)

Text-mined interactions from Literome

Channavajhala et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Although KSR is a positive regulator of the Ras/mitogen activated protein ( MAP ) kinase pathway, the role of KSR in Cot mediated MAPK activation has not been identified
Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
López-Pelaéz et al., Mol Biol Cell 2012 (Inflammation...) : Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages
Roget et al., Mol Cell Biol 2012 : The IKK complex therefore regulates two of the key regulatory steps required for TPL-2 activation of ERK-1/2 , underlining the close linkage of ERK-1/2 MAP kinase activation to upregulation of NF-?B dependent transcription
Sanz-Garcia et al., J Biol Chem 2013 (Drug-Induced Liver Injury...) : Cot/tpl2 ( MAP3K8 ) activates MKK1/2-Erk1/2 following stimulation of the Toll-like/IL-1 receptor superfamily
Tsatsanis et al., Oncogene 1998 (Lymphoma, T-Cell) : Since the activation of NFAT is MAPK dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2