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MMP9 — NAMPT

Text-mined interactions from Literome

Adya et al., Cardiovasc Res 2008 : Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways : novel insights into visfatin induced angiogenesis ... Inhibition of VEGFR2 and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] down-regulated visfatin induced MMP induction ... Inhibition of PI3K/Akt and ERK ( 1/2 ) pathways led to significant decrease of visfatin induced MMP and VEGF production and activation, along with significant reduction in endothelial proliferation and capillary tube formation ... Our data provide the first evidence of visfatin induced endothelial VEGF and MMP production and activity
Adya et al., Diabetes Care 2008 (Diabetes Mellitus, Type 2...) : Furthermore, the NF-kappaB inhibitor significantly negated visfatin induced matrix metalloproteinase (MMP)-2/9 mRNA expression, protein levels, and gelatinolytic activity ( P < 0.001 )
Huang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2010 : [ Visfatin upregulates MMP-2 and MMP-9 expressions in human monocytes through activating NF-kappaB ] ... To investigate the effects of visfatin on the MMP-2 and MMP-9 expressions in human monocytes and related mechanisms ... Visfatin enhanced the expression and activity of MMP-2 and MMP-9 in human monocytes via activating NF-kappaB signaling pathway
Fan et al., Int J Mol Med 2011 (Plaque, Atherosclerotic) : Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK ( p38, ERK1/2 ) -NF-?B signaling pathway ... Visfatin ( 50-400 ng/ml ) induced EMMPRIN and MMP-9 depending on the dosage used ... Exogenous nicotinamide mononucleotide ( NMN ), the product of nicotinamide phosphoribosyltransferase ( NAMPT ) activity, mimicked the effects of visfatin on MAPK ( p38, ERK1/2 ) -NF-?B activation and EMMPRIN/MMP-9 induction ... Retinoid X receptor ( RXR ) agonist suppressed the effects of visfatin on EMMPRIN/MMP-9 , NF-?B, but not on MAPK activation
Lappas et al., Mol Cell Endocrinol 2012 : There was, however, no effect of visfatin on pro MMP-9 enzyme activity