◀ Back to TRAF6

IRAK1 — TRAF6

Pathways - manually collected, often from reviews:

• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta toll-like receptor pathway: Imiquimod/TLR7/TLR7/MYD88/IRAK complex (MYD88-TLR7-IRAK1) → TRAF6 (modification, activates)
• BioCarta toll-like receptor pathway: Poly (I:c)TLR3/TLR3/MYD88/IRAK complex (IRAK1-MYD88-TLR3) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IL-1-alpha (IL1A) (modification, collaborate)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: IL-1-alpha (IL1A) → IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: CpG DNA/TLR9/TLR9/MYD88/IRAK complex (IRAK1-TLR9-MYD88) → TRAF6 (modification, activates)
• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) → TRAF6 (modification, activates)
• BioCarta signal transduction through il1r: IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → TAB1/TAK1 complex (MAP3K7IP1-MAP3K7) (modification, activates)
  
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta toll-like receptor pathway: LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) (modification, collaborate)
• BioCarta nf-kb signaling pathway: TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) → LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: None → LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• KEGG Toll-like receptor signaling pathway: Complex of IRAK1-IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Neurotrophin signaling pathway: Complex of IRAK1-IRAK2-IRAK3-IRAK4-TRAF6 → IKBKB (protein-protein, activation)
• KEGG Leishmaniasis: IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Chagas disease (American trypanosomiasis): IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Toxoplasmosis: IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Tuberculosis: IRAK1/IRAK2 → TRAF6 (protein-protein, activation)
• KEGG Measles: IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: Atypical PKCs (PRKCI/PRKCZ) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Sanz et al., EMBO J 2000
  Evidence: physical interaction
• NCI Pathway Database IL1-mediated signaling events: Atypical PKCs (PRKCI/PRKCZ) → IRAK/TRAF6/p62/Atypical PKCs complex (IRAK1-TRAF6-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
  Sanz et al., EMBO J 2000
  Evidence: physical interaction
• NCI Pathway Database IL1-mediated signaling events: p62 (SQSTM1) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Sanz et al., EMBO J 2000
  Evidence: physical interaction
• NCI Pathway Database IL1-mediated signaling events: p62 (SQSTM1) → IRAK/TRAF6/p62/Atypical PKCs complex (IRAK1-TRAF6-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
  Sanz et al., EMBO J 2000
  Evidence: physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IRAK/TRAF6/p62/Atypical PKCs complex (IRAK1-TRAF6-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
  Sanz et al., EMBO J 2000
  Evidence: physical interaction
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/TRKA complex (NTRK1-NGF) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, inhibits)
  Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
  Evidence: mutant phenotype, reporter gene, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
  Evidence: mutant phenotype, reporter gene, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → Atypical PKCs (PRKCI/PRKCZ) (modification, collaborate)
  Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → p62 (SQSTM1) (modification, collaborate) Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
  Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: Atypical PKCs (PRKCI/PRKCZ) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
  Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: p62 (SQSTM1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
  Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → UBC13/UEV1A complex (UBE2N-UBE2V1) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/MEKK3 complex (IRAK1-TRAF6-MAP3K3) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Yao et al., J Biol Chem 2007*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/MEKK3 complex (IRAK1-TRAF6-MAP3K3) → MEKK3 (MAP3K3) (modification, collaborate) Yao et al., J Biol Chem 2007*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → MEKK3 (MAP3K3) (modification, collaborate) Yao et al., J Biol Chem 2007*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IRAK (IRAK1) (modification, collaborate) Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, activates)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IRAK (IRAK1) (modification, collaborate) Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → UBC13/UEV1A complex (UBE2N-UBE2V1) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database p75(NTR)-mediated signaling: MYD88 (MYD88) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) (modification, activates)
  Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2 complex (NGF-NGFR-TRAF6-RIPK2) (modification, collaborate)
  Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → IRAK (IRAK1) (modification, collaborate) Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2 complex (NGF-NGFR-TRAF6-RIPK2) → IRAK (IRAK1) (modification, collaborate) Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• Reactome Reaction: TRAF6 → IRAK1 (reaction) Lallena et al., Mol Cell Biol 1999, Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Kawai et al., Nat Immunol 2004, Lamothe et al., J Biol Chem 2007, Butler et al., J Biol Chem 2007, Ordureau et al., Biochem J 2008, Muroi et al., J Leukoc Biol 2008, Conze et al., Mol Cell Biol 2008, Ning et al., Mol Cell Biol 2008, Newton et al., Cell 2008, Smith et al., Proc Natl Acad Sci U S A 2009, Cao et al., Nature 1996, Khursigara et al., J Biol Chem 1999
• Reactome Reaction: TRAF6 → IRAK1 (indirect_complex) Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Lamothe et al., J Biol Chem 2007, Muroi et al., J Leukoc Biol 2008, Cao et al., Nature 1996
• Reactome Reaction: TRAF6 → IRAK1 (direct_complex) Lallena et al., Mol Cell Biol 1999, Sanz et al., EMBO J 2000, Wooten et al., J Biol Chem 2001, Butler et al., J Biol Chem 2007, Ordureau et al., Biochem J 2008, Conze et al., Mol Cell Biol 2008, Newton et al., Cell 2008, Khursigara et al., J Biol Chem 1999
• Reactome Reaction: IRAK1 → TRAF6 (direct_complex) Yang et al., Biochem Biophys Res Commun 2004*
• WikiPathways EBV LMP1 signaling: TRADD/IRAK1 → MAP3K7/TAB1/MAP3K3/TRAF6 (unknown)
• WikiPathways Interleukin-1 Induced Activation of NF-kappa-B: Complex of AJUBA-PRKCZ-TIFA-SQSTM1-UBE2N-UBE2V1-TRAF6-IRAK1 → NFKB1 (activation)
• WikiPathways Interleukin-1 Induced Activation of NF-kappa-B: Complex of TRAF6-UBE2V1-TIFA-UBE2N-IRAK1 → Complex of AJUBA-PRKCZ-TIFA-SQSTM1-UBE2N-UBE2V1-TRAF6-IRAK1 (activation)
  
• WikiPathways Interleukin-1 Induced Activation of NF-kappa-B: IL1A → Complex of TRAF6-UBE2V1-TIFA-UBE2N-IRAK1 (activation)
  
• WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway: TLR1/TLR2/TLR4/TLR5/TLR6/TLR7/TLR8/TLR9/TLR10/IL1A → Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1 (activation)
  
• WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway: Complex of TRAF6-TIFA-IRAK1-UBE2N-UBE2V1 → NFKB1 (activation)
• WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway: Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1 → Complex of TRAF6-TIFA-IRAK1-UBE2N-UBE2V1 (activation)
  
• WikiPathways TLR4 Signaling and Tolerance: Complex of IRAK1-MYD88-IRAK4 → TRAF6 (activation)
• WikiPathways Toll-like Receptor Signaling: Complex of IRAK4-IRAK1 → TRAF6 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: TRAF6 — IRAK1 (coimmunoprecipitation) Zhou et al., Cancer Cell 2005*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Lee et al., Biochim Biophys Acta 2009*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Nguyen et al., Cell Signal 2009*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Lakshmanan et al., J Immunol 2007*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Lee et al., Journal of neuroinflammation 2012*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Zhang et al., Cell Res 2013*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Yao et al., J Biol Chem 2007*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Wesche et al., J Biol Chem 1999
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Qian et al., J Biol Chem 2001*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Cao et al., Nature 1996
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Ling et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Biogrid Interaction: TRAF6 — IRAK1 (direct interaction, pull down) Liu et al., J Biol Chem 2012*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Takatsuna et al., J Biol Chem 2003*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (direct interaction, two hybrid) Takaesu et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Muzio et al., Science 1997
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Chen et al., Cell Signal 2008*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Li et al., Proc Natl Acad Sci U S A 2001
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Xiong et al., J Biol Chem 2011
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Tang et al., FEBS Lett 2010*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Muroi et al., Biochim Biophys Acta 2012*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Liu et al., J Immunol 2007*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Kollewe et al., J Biol Chem 2004
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Jiang et al., Mol Cell Biol 2002
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Jensen et al., J Biol Chem 2001*
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Jiang et al., J Biol Chem 2003
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Rao et al., Mol Cell Biol 2005
• IRef Biogrid Interaction: TRAF6 — IRAK1 (physical association, affinity chromatography technology) Choi et al., Nat Immunol 2006*
• IRef Hprd Interaction: Complex of 17 proteins Windheim et al., Mol Cell Biol 2008
• IRef Hprd Interaction: IRAK1 — TRAF6 (in vivo) Baud et al., Genes Dev 1999*, Cao et al., Nature 1996
• IRef Hprd Interaction: IRAK1 — TRAF6 (in vitro) Baud et al., Genes Dev 1999*, Cao et al., Nature 1996
• IRef Innatedb Interaction: Complex of TRAF6-MAP3K3-IRAK1 (unknown, -) Yao et al., J Biol Chem 2007*
• IRef Innatedb Interaction: Complex of IRAK1-TRAF6-TAB2 (unknown, -) Takaesu et al., Mol Cell Biol 2001*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Cao et al., Nature 1996
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Zhande et al., Mol Cell Biol 2007*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Lee et al., Biochim Biophys Acta 2009*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Wesche et al., J Biol Chem 1999
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Takaesu et al., Mol Cell Biol 2001*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Ling et al., Proc Natl Acad Sci U S A 2000*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Rao et al., Mol Cell Biol 2005
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Zhou et al., Cancer Cell 2005*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Xiong et al., J Biol Chem 2011
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Alvarez et al., J Immunol 2006*
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Muzio et al., Science 1997
• IRef Innatedb Interaction: TRAF6 — IRAK1 (unknown, -) Muroi et al., Biochim Biophys Acta 2012*
• IRef Intact Interaction: Complex of 18 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of IRAK4-TRAF6-PELI1-IRAK1 (association, anti tag coimmunoprecipitation) Jiang et al., J Biol Chem 2003
• IRef Intact Interaction: TRAF6 — IRAK1 (physical association, anti tag coimmunoprecipitation) Wesche et al., J Biol Chem 1999
• IRef Intact Interaction: TRAF6 — IRAK1 (physical association, coimmunoprecipitation) Qian et al., J Biol Chem 2001*
• IRef Intact Interaction: TRAF6 — IRAK1 (physical association, anti bait coimmunoprecipitation) Jiang et al., Mol Cell Biol 2002
• IRef Ophid Interaction: TRAF6 — IRAK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Jefferies et al., Mol Cell Biol 2001 : Dominant negative RacN17 inhibited wild-type IRAK-1- and TRAF-6 induced transactivation, and in turn, dominant negative IRAK-1 and TRAF-6 inhibited the RacV12-driven response, suggesting a mutual codependence of Rac1, IRAK-1, and TRAF-6 in regulating this pathway
Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Yanagisawa et al., Biochem J 2003 : To clarify the mechanism of NF-kappaB activation by IRAK-1-S in the absence of binding to TRAF6, we demonstrated that IRAK-1-S binds to IRAK-1-W through its death domain ; the findings suggested that overexpressed IRAK-1-S may bind endogenous IRAK-1-W and activate TRAF6 through IRAK-1-W
Keating et al., J Biol Chem 2007 : Expression of IRAK-2, but not IRAK-1 , led to TRAF6 ubiquitination, an event critical for NFkappaB activation