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BCR — CD22
Text-mined interactions from Literome
Viemann et al., Eur J Immunol 2000
:
On the other hand, up-regulation of
CD22 after TD stimulation may
allow increased inhibiting influence of CD22 on neonatal
BCR signaling, impairing B cell activation and differentiation
Lajaunias et al., J Immunol 2002
(Calcium Signaling) :
Moreover, in CD22-deficient mice, anti-IgM treatment did not trigger enhanced Ca ( 2+ ) influx in CD5 ( + ) B-1 cells, unlike CD22-deficient splenic B-2 cells, suggesting a relatively limited
role of
CD22 in
BCR signaling in B-1 cells
Mattsson et al., Cell Immunol 2005
(Autoimmune Diseases...) :
While normal B-lymphocytes require IL-4 to achieve down-modulation of
CD22 expression in
response to
BCR cross linking, culture with anti-IgM alone led to reduced CD22 expression in fsn/fsn mice
Lee et al., J Immunol 2005
:
BCR induced
CD22 phosphorylation and Src homology 2 domain containing protein tyrosine phosphatase-1/CD22 associations were also reduced, suggesting abrogation of negative regulatory signaling ... By contrast, CD19/CD21 ligation using higher concentrations of SA-C3dg significantly inhibited
BCR induced [ Ca2+ ] i responses and
inhibited CD19, Lyn,
CD22 , and Syk phosphorylation
Ghosh et al., Int Immunol 2006
:
This points to a new mechanism of
BCR signal
regulation by
CD22 and its ligand
Fujimoto et al., J Dermatol Sci 2007
(Autoimmune Diseases) :
CD19 and
CD22 do not merely
regulate BCR signals independently, but they have their own regulatory network
Yu et al., Biochem Biophys Res Commun 2007
:
Previous studies demonstrated that synthetic sialosides that bind to CD22 augment BCR signaling by inhibiting
CD22 mediated
BCR regulation ... Because
CD22 mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is
activated by
BCR , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation
Zhu et al., J Biol Chem 2008
:
Here we address the requirement of CD22 for SHP-1 recruitment and BCR regulation upon
BCR ligation by antigen, which
induces much stronger
CD22 phosphorylation than anti-Ig Ab does ... We demonstrate that the
CD22 mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and
regulates BCR signaling upon stimulation with antigen but not anti-Ig Ab
Gross et al., J Immunol 2009
:
The
effects of
CD22 deficiency on
BCR signaling were very similar in B cells at different stages of maturation
Harvey et al., BioDrugs 2013
(Lupus Erythematosus, Systemic) :
Epratuzumab is a humanized monoclonal antibody that targets CD22 on B cells and results in modulation of B-cell function and migration, as
CD22 regulates adhesion and
inhibits B-cell receptor (BCR) signalling
Sato et al., Proc Natl Acad Sci U S A 1997
:
Ligation of CD19 and
CD22 in vivo is likely to positively and negatively
regulate BCR signaling, respectively, because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation
Chan et al., Curr Biol 1998
:
Surprisingly, CD22 remains capable of regulating the ERK2 and JNK pathways in lyn-/- B cells, which may relate to the small residual increase in
BCR induced
CD22 phosphorylation