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MAPK3 — PIK3CG
Text-mined interactions from Literome
Baier et al., Cell Growth Differ 1999
:
Our findings suggest that sustained
MAPK activation via
PI3Kgamma precedes ATRA -dependent differentiation or growth inhibition
Hehl et al., Biochem J 2001
:
Expression of a constitutive active
PI3Kgamma ( PI3Kgamma-CAAX ) induced GVBD and
increased the levels of phosphorylated Akt/protein kinase B and
mitogen activated protein kinase ( MAPK )
Oudit et al., Circulation 2003
(Cardiomegaly...) :
The lack of
PI3Kgamma attenuated the activation of Akt/protein kinase B and
extracellular signal regulated kinase 1/2 signaling pathways in cardiac myocytes in response to isoproterenol
Bondeva et al., Science 1998
:
Phosphoinositide 3-kinases (PI3Ks) activate protein kinase PKB ( also termed Akt ), and
PI3Kgamma activated by heterotrimeric guanosine triphosphate binding protein can
stimulate mitogen activated protein kinase ( MAPK ) ... Membrane targeted
PI3Kgamma constitutively produced phosphatidylinositol 3,4, 3,4,5-trisphosphate and
activated PKB but not
MAPK ... Moreover, stimulation of
MAPK in response to lysophosphatidic acid was
blocked by catalytically inactive
PI3Kgamma but not by hybrid PI3Kgammas