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MMP9 — WDR61
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Ottino et al., Invest Ophthalmol Vis Sci 2005
:
PAF , through a receptor mediated mechanism,
induces a specific pattern of furin,
MMP , and TIMP-2 expression in corneal myofibroblasts
Ko et al., FEBS Lett 2005
:
PAF increased mRNA expression, protein synthesis, and
MMP-9 activity in ECV304 cells, in a NF-kappaB dependent manner ...
PAF increased
MMP-9 promoter activity in ECV304, which was inhibited by WEB2107, and NF-kappaB inhibitors
Ko et al., FEBS Lett 2005
:
Recently, we reported that
PAF upregulates
MMP-9 expression in a NF-kappaB dependent manner ... In this study, we investigated the signaling pathway involved in
PAF induced
MMP-9 expression in ECV304 cells ... Our current data indicate that the Ca ( 2+ ) - or phosphatidylinositol 3-kinase (PI3K) dependent signaling pathway is necessary for
PAF induced
MMP-9 expression ... Our results suggest that
PAF induced
MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways
Zhou et al., Am J Physiol Heart Circ Physiol 2007
:
Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that PAF induced the release of HB-EGF within 1 min. Gelatin zymography data showed that
PAF stimulated MMP-2 activity and
MMP-9 activity within 1 min
Taheri et al., Invest Ophthalmol Vis Sci 2007
:
Here the transcriptional
regulation of
MMP-9 gene expression by
PAF was investigated in human corneal epithelial cells ( HCECs ) ... A region spanning -670 to -460 relative to the transcription start point was required for the
induction of the
MMP-9 promoter by
PAF ... These findings demonstrate that collaboration between several regulatory elements is required for the
induction of
MMP-9 promoter activity by
PAF and that PAF overturns the repressor effect of Sp1 through activation of the MEK/ERK signaling cascade
Kakazu et al., Exp Eye Res 2012
(Disease Models, Animal...) :
PAF increased
MMP-9 and decreased FN expression compared to vehicle treatment and less a-SMA positive cells migrated to the wounded area
Okada et al., Am J Respir Cell Mol Biol 1997
:
Release of
MMP-9 by eosinophils was
increased by IL-5,
PAF , or both, but the substrate degrading activity of MMP-9 was increased only in the presence of both IL-5 and PAF, indicating that the releasing and activating mechanisms of MMP-9 are involved in eosinophil basement membrane migration