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CDKN1A — SIRT1

Text-mined interactions from Literome

Kataoka et al., Cancer Res 2003 (Carcinoma, Hepatocellular...) : Both ING1 and p53 were able to suppress AFP transcription and cause p21 induction ; hSIR2 , a negative regulator of the p53 protein, showed the opposite effects on the AFP promoter and, like HDAC1, repressed p21 promoter activity
Yamakuchi et al., Proc Natl Acad Sci U S A 2008 : MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively
Lee et al., Cancer Lett 2013 (Aging, Premature...) : Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21 ( WAF1 ) by inhibiting p53 binding to the promoter