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SST — SSTR1

Pathways - manually collected, often from reviews:

• Reactome Reaction: SST → SSTR1 (direct_complex) Yamada et al., Mol Endocrinol 1992*, Yamada et al., Proc Natl Acad Sci U S A 1992*, Yamada et al., Biochem Biophys Res Commun 1993*
• Reactome Reaction: SST → SSTR1 (reaction) Yamada et al., Mol Endocrinol 1992*, Yamada et al., Proc Natl Acad Sci U S A 1992*, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994, Yamada et al., Biochem Biophys Res Commun 1993*
• WikiPathways Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways: SST → SSTR1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SSTR1 — SST (in vivo) Yamada et al., Proc Natl Acad Sci U S A 1992*
• IRef Ophid Interaction: SSTR1 — SST (aggregation, confirmational text mining) Yamada et al., Proc Natl Acad Sci U S A 1992*
• IRef Ophid Interaction: SSTR1 — SST (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kreienkamp et al., FEBS Lett 1999 : The various functions of SST are mediated through at least five different receptor subtypes ( SSTR1-5 ), their precise physiological roles have not been solved yet
Florio et al., J Physiol Paris 2000 (MAP Kinase Signaling System) : Thus, the activation of SHP-2 by SSTR1 may mediate the antiproliferative activity of somatostatin
Li et al., Cancer 2011 (Carcinoma, Pancreatic Ductal...) : Somatostatin (SST) inhibited cell proliferation and negatively regulated the release of growth hormones by means of specific receptors ( SSTR )
Hou et al., J Biol Chem 1994 : In contrast, only SSTR1 mediated somatostatin inhibition of Na ( + ) -H+ exchange activity, and this action was insensitive to pertussis toxin
Schäfer et al., Z Ernahrungswiss 1998 : Localization of somatostatin receptor subtype mRNA in the rat gastrointestinal tract and regulation of SSTR1 gene expression
Peng et al., Int J Mol Med 1998 : These findings show that SSTR is expressed in skeletal muscle and that SST acting via the SSTR regulates tyrosine phosphorylation and expression of the epsilon subunit of the AChR in the rat skeletal muscle
Florio et al., Mol Endocrinol 1999 : Somatostatin activation of mitogen activated protein kinase via somatostatin receptor 1 (SSTR1)