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RAC1 — TLN1

Pathways - manually collected, often from reviews:

• BioCarta ucalpain and friends in cell spread: RAC1 → Talin (TLN1) (modification, activates)
• BioCarta ucalpain and friends in cell spread: RAC1 → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, activates)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 185 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 177 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012

Text-mined interactions from Literome

Nishimura et al., Blood 2012 (Thrombosis) : Actin linker talin dependent activation of alphaIIb-beta3 integrin or Rac1 in platelets was required for late-phase thrombus stability
Wang et al., J Cell Biol 2012 : Tiam1 interaction with the PAR complex promotes talin mediated Rac1 activation during polarized cell migration ... The interactions of talin with Tiam1 and the PAR complex were required for adhesion induced Rac1 activation, cell spreading, and migration toward integrin substrates