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NOTCH3 — SLC22A3

Text-mined interactions from Literome

Timmerman et al., Genes Dev 2004 (Cell Transformation, Neoplastic) : Here we demonstrate that Notch activity promotes EMT during both cardiac development and oncogenic transformation via transcriptional induction of the Snail repressor, a potent and evolutionarily conserved mediator of EMT in many tissues and tumor types
Zavadil et al., EMBO J 2004 : Our findings identify a new mechanism for functional integration of Jagged1/Notch signalling and coordinated activation of the Hey1 transcriptional repressor controlled by TGF-beta/Smad3, and demonstrate functional roles for Smad3, Hey1, and Jagged1/Notch in mediating TGF-beta induced EMT
Moustakas et al., Cancer Sci 2007 (Cell Transformation, Neoplastic...) : Transforming growth factor-beta, Wnt, Notch and growth factors acting through tyrosine kinase receptors induce EMT and often act in a sequential manner
Chen et al., Br J Cancer 2010 (Anoxia...) : Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the Notch signaling pathway, and JAGGED1 induced Notch activation increases EMT
MacGrogan et al., Birth Defects Res A Clin Mol Teratol 2011 (Heart Defects, Congenital) : During cardiac valve formation, endocardial Notch signaling activates the epithelial-mesenchyme transition (EMT) that will give rise to the cardiac valve primordia
Gupta et al., Gynecol Oncol 2013 (Ovarian Neoplasms) : Activation of Notch3 in OVCA429 cells causes a spindle and fibroblast-like morphology, induces the expression of smooth muscle a-actin, Slug and Snail, but decreases the expression of E-cadherin, indicating that Notch3 activation induces EMT in OVCA429 cells ... Notch3 activation induces EMT and attenuates carboplatin induced apoptosis in OVCA429 cells