◀ Back to SMARCC1
SMARCC1 — SMARCE1
Pathways - manually collected, often from reviews:
-
BioCarta chromatin remodeling by hswi/snf atp-dependent complexes:
glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor complex (NR3C1)
→
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta chromatin remodeling by hswi/snf atp-dependent complexes:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF complex (NR3C1-NF1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta chromatin remodeling by hswi/snf atp-dependent complexes:
NF1
→
glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF/NF1 complex (NR3C1-NF1-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta chromatin remodeling by hswi/snf atp-dependent complexes:
glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF complex (NR3C1-NF1)
→
glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF/NF1 complex (NR3C1-NF1-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta chromatin remodeling by hswi/snf atp-dependent complexes:
glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF/NF1 complex (NR3C1-NF1-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, activates)
-
BioCarta control of gene expression by vitamin d receptor:
NCOA62/TSC2/TRAP220 complex (SKIIP-TSC2-PPARBP)
→
RXR/VDR/WSTF/WINAC complex (RXRA-VDR-BAZ1B-SMARCE1-SMARCC2-SMARCC1-SMARCD1-ARID1A-SMARCA4-ACTL6A-TOP2B-CHAF1A-SUPT16H)
(transcription, activates)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of 17 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 16 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Zhao et al., Cell 1998
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Hu et al., Nat Genet 2006*
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Kaeser et al., J Biol Chem 2008
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Ryme et al., J Cell Biochem 2009
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Chen et al., Mol Cell Biol 2005*
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(direct interaction, pull down)
Chen et al., Mol Cell Biol 2005*
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Keppler et al., J Biol Chem 2010*
-
IRef Biogrid Interaction:
SMARCC1
—
SMARCE1
(physical association, affinity chromatography technology)
Mak et al., Mol Cell Proteomics 2010
-
MIPS CORUM WINAC complex:
WINAC complex complex (ACTL6A-ARID1A-BAZ1B-CHAF1A-SMARCA2-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1-SUPT16H-TOP2B-VDR)
Kitagawa et al., Cell 2003
-
MIPS CORUM BAF complex:
BAF complex complex (ACTL6A-ARID1A-SMARCA2-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1)
Nie et al., Mol Cell Biol 2000
-
MIPS CORUM PBAF complex (Polybromo- and BAF containing complex):
PBAF complex (Polybromo- and BAF containing complex) complex (ACTL6A-ARID2-PBRM1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1)
Lemon et al., Nature 2001
-
MIPS CORUM EBAFb complex:
EBAFb complex complex (ACTL6A-ARID1B-MLLT1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCE1)
Nie et al., Mol Cell Biol 2003
-
MIPS CORUM BAF complex:
BAF complex complex (ACTL6A-ARID1A-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1-SMARCA2-SMARCA4)
Nie et al., Mol Cell Biol 2003
-
MIPS CORUM EBAFa complex:
EBAFa complex complex (ACTL6A-ARID1A-MLLT1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCE1)
Nie et al., Mol Cell Biol 2003
-
MIPS CORUM PBAF complex (Polybromo- and BAF containing complex):
PBAF complex (Polybromo- and BAF containing complex) complex (ARID2-PBRM1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1-ACTB-ACTG1-ACTL6A-ACTL6B)
Xue et al., Proc Natl Acad Sci U S A 2000
-
MIPS CORUM BAF complex:
BAF complex complex (SMARCA2-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1-ACTB-ACTG1-ACTL6A-ACTL6B-ARID1A-ARID1B)
Xue et al., Proc Natl Acad Sci U S A 2000
-
MIPS CORUM SWI-SNF chromatin remodeling-related-BRCA1 complex:
SWI-SNF chromatin remodeling-related-BRCA1 complex complex (ACTL6A-BRCA1-SMARCA2-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD2-SMARCE1-ARID1A-ARID1B)
Bochar et al., Cell 2000
-
MIPS CORUM RNA polymerase II complex, chromatin structure modifying:
RNA polymerase II complex, chromatin structure modifying complex (ACTL6A-CCNC-CDK8-MED21-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCD1-SMARCD2-SMARCD3)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM PBAF complex (Polybromo- and BAF containing complex):
PBAF complex (Polybromo- and BAF containing complex) complex (ACTL6A-ARID2-PBRM1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCE1)
Lemon et al., Nature 2001
-
MIPS CORUM BAF complex:
BAF complex complex (ACTL6A-ARID1A-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCE1)
Lemon et al., Nature 2001
-
MIPS CORUM PBAF complex (Polybromo- and BAF containing complex):
PBAF complex (Polybromo- and BAF containing complex) complex (ACTL6A-ARID2-PBRM1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1)
Yan et al., Genes Dev 2005
-
MIPS CORUM BAF complex:
BAF complex complex (ACTL6A-ARID1A-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCA2-SMARCA4-SMARCD1-SMARCD2-SMARCD3)
Wang et al., EMBO J 1996
-
MIPS CORUM PBAF complex (Polybromo- and BAF containing complex):
PBAF complex (Polybromo- and BAF containing complex) complex (ACTL6A-ARID2-PBRM1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCD1-SMARCD2-SMARCD3)
Wang et al., EMBO J 1996
-
MIPS CORUM BAF complex:
BAF complex complex (ACTB-ACTL6A-ARID1A-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCD1-SMARCD2-SMARCD3)
Zhao et al., Cell 1998
-
MIPS CORUM Brg1-associated complex I:
Brg1-associated complex I complex (ACTL6A-ARID1A-PRMT5-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCD1-SMARCD2-SMARCD3)
Sif et al., Genes Dev 2001
-
MIPS CORUM Brm-associated complex:
Brm-associated complex complex (ACTL6A-ARID1A-PRMT5-SMARCA2-SMARCB1-SMARCC1-SMARCC2-SMARCE1-SMARCD1-SMARCD2-SMARCD3)
Sif et al., Genes Dev 2001
-
MIPS CORUM BRG1-SIN3A complex:
BRG1-SIN3A complex complex (ACTL6A-ARID1A-HDAC2-PRMT5-RBBP4-SIN3A-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCD3-SMARCE1)
Sif et al., Genes Dev 2001
-
MIPS CORUM BRM-SIN3A complex:
BRM-SIN3A complex complex (ACTL6A-ARID1A-HDAC1-HDAC2-PRMT5-RBBP4-SIN3A-SMARCA2-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCD3-SMARCE1)
Sif et al., Genes Dev 2001
-
MIPS CORUM LARC complex (LCR-associated remodeling complex):
LARC complex (LCR-associated remodeling complex) complex (ACTB-ACTL6A-ARID1A-CHD4-DPF2-GATAD2B-HDAC1-HDAC2-HNRNPC-MBD2-MBD3-MTA2-RBBP4-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD2-SMARCE1)
Mahajan et al., Proc Natl Acad Sci U S A 2005
-
MIPS CORUM BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I:
BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I complex (ACTL6A-ARID1A-HDAC2-PRMT5-SIN3A-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1)
Pal et al., Mol Cell Biol 2003
-
MIPS CORUM BRM-SIN3A-HDAC complex:
BRM-SIN3A-HDAC complex complex (ACTL6A-ARID1A-HDAC2-PRMT5-SIN3A-SMARCA2-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCE1)
Pal et al., Mol Cell Biol 2003
-
MIPS CORUM BRG1-associated complex:
BRG1-associated complex complex (ACTL6A-ARID1A-PRMT5-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1)
Pal et al., Mol Cell Biol 2003
-
MIPS CORUM BRM-associated complex:
BRM-associated complex complex (ACTL6A-ARID1A-PRMT5-SMARCA2-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCD2-SMARCE1)
Pal et al., Mol Cell Biol 2003
-
MIPS CORUM NUMAC complex (nucleosomal methylation activator complex):
NUMAC complex (nucleosomal methylation activator complex) complex (ACTB-ARID1A-CARM1-SCYL1-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1-SMARCE1)
Xu et al., Genes Dev 2004
-
IRef Corum Interaction:
Complex of 39 proteins
(association, affinity chromatography technology)
Mahajan et al., Proc Natl Acad Sci U S A 2005
-
IRef Corum Interaction:
Complex of 37 proteins
(association, anti bait coimmunoprecipitation)
Pal et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 23 proteins
(association, affinity chromatography technology)
Wang et al., EMBO J 1996
-
IRef Corum Interaction:
Complex of 21 proteins
(association, anti bait coimmunoprecipitation)
Nie et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 28 proteins
(association, anti bait coimmunoprecipitation)
Lemon et al., Nature 2001
-
IRef Corum Interaction:
Complex of 21 proteins
(association, anti bait coimmunoprecipitation)
Nie et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 21 proteins
(association, affinity chromatography technology)
Pal et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 23 proteins
(association, affinity chromatography technology)
Wang et al., EMBO J 1996
-
IRef Corum Interaction:
Complex of 34 proteins
(association, cosedimentation through density gradient)
Pal et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of ACTL6A-ARID1A-SMARCC1-SMARCA4-SMARCC2-SMARCB1-SMARCD2-SMARCE1-SMARCD1
(association, ion exchange chromatography)
Lemon et al., Nature 2001
-
IRef Corum Interaction:
Complex of 23 proteins
(association, molecular sieving)
Bochar et al., Cell 2000
-
IRef Corum Interaction:
Complex of 27 proteins
(association, affinity chromatography technology)
Xue et al., Proc Natl Acad Sci U S A 2000
-
IRef Corum Interaction:
Complex of 29 proteins
(association, cosedimentation through density gradient)
Sif et al., Genes Dev 2001
-
IRef Corum Interaction:
Complex of 28 proteins
(association, molecular sieving)
Nie et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 19 proteins
(association, affinity chromatography technology)
Pal et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 21 proteins
(association, affinity chromatography technology)
Xu et al., Genes Dev 2004
-
IRef Corum Interaction:
Complex of 23 proteins
(association, anti tag coimmunoprecipitation)
Sif et al., Genes Dev 2001
-
IRef Corum Interaction:
Complex of 11 proteins
(association, ion exchange chromatography)
Lemon et al., Nature 2001
-
IRef Corum Interaction:
Complex of 23 proteins
(association, cosedimentation through density gradient)
Sif et al., Genes Dev 2001
-
IRef Corum Interaction:
Complex of 12 proteins
(association, anti bait coimmunoprecipitation)
Zhao et al., Cell 1998
-
IRef Corum Interaction:
Complex of 12 proteins
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of 43 proteins
(association, cosedimentation through density gradient)
Kitagawa et al., Cell 2003
-
IRef Corum Interaction:
Complex of 31 proteins
(association, cosedimentation through density gradient)
Sif et al., Genes Dev 2001
-
IRef Corum Interaction:
Complex of 25 proteins
(association, affinity chromatography technology)
Xue et al., Proc Natl Acad Sci U S A 2000
-
IRef Dip Interaction:
Complex of SMARCA4-PBRM1-SMARCC1-SMARCC2-ARID2-SMARCE1-CHD7-BRD7
(anti bait coimmunoprecipitation)
Bajpai et al., Nature 2010
-
IRef Dip Interaction:
Complex of 11 proteins
(anti bait coimmunoprecipitation)
Bajpai et al., Nature 2010
-
IRef Hprd Interaction:
Complex of 197 proteins
(in vivo)
Kitagawa et al., Cell 2003
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Harikrishnan et al., Nat Genet 2005
-
IRef Hprd Interaction:
Complex of 65 proteins
(in vivo)
Kato et al., J Biol Chem 2002
-
IRef Hprd Interaction:
Complex of 343 proteins
(in vivo)
Lemon et al., Nature 2001
-
IRef Hprd Interaction:
Complex of 122 proteins
(in vivo)
Phelan et al., Mol Cell 1999, Xue et al., Proc Natl Acad Sci U S A 2000
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Lemon et al., Nature 2001
-
IRef Hprd Interaction:
Complex of 801 proteins
(in vivo)
Ingham et al., Mol Cell Biol 2005
-
IRef Intact Interaction:
Complex of ARID1A-SMARCA4-SMARCB1-SMARCE1-SMARCD2-SMARCC1-SMARCC2-SRGAP3
(association, coimmunoprecipitation)
Olave et al., Genes Dev 2002
-
IRef Intact Interaction:
Complex of PBRM1-ARID2-SMARCC1-SMARCC2-SMARCB1-SMARCE1-SMARCA4
(association, anti tag coimmunoprecipitation)
Yan et al., Genes Dev 2005
-
IRef Intact Interaction:
Complex of PBRM1-SMARCE1-SMARCD2-ACTL6A-SMARCC1-SMARCC2-SMARCB1-SMARCA4-SMARCD1
(physical association, ion exchange chromatography)
Lemon et al., Nature 2001
Text-mined interactions from Literome
Low et al., Oncogene 1999
:
Fas ligation in the presence of cycloheximide induced Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation, caspase activation and cell death in the
IL-3 dependent cell line
BAF3
Lock et al., J Biol Chem 1999
:
Immunoprecipitation experiments using DokR-specific antibodies revealed an interaction between endogenous DokR and a 150-kDa protein that is tyrosine phosphorylated in
EGF stimulated
BaF/3 cells
Delaney et al., J Neurobiol 1999
:
Caspase-3 activity was rapidly activated upon serum withdrawal in SC, and the caspase inhibitor
BAF blocked apoptosis
Shimamoto et al., Exp Hematol 2000
:
In this study, we have constructed an expression vector encoding human DLX-7, and examined the effects of overexpression of DLX-7 in the
IL-3 dependent lymphoid precursor cell line
Ba/F3
Demoulin et al., FEBS Lett 2000
:
We observed a
PI 3-K dependent phosphorylation of protein kinase B (PKB) in TS1 cells, but not in
BaF/9R , nor in other IL-9 dependent cell lines
Schutyser et al., J Immunol 2000
(Cell Transformation, Neoplastic) :
Although coinduced with monocyte chemotactic protein-1 (MCP-1) and IL-8 by dsRNA, measles virus, and IL-1beta in diploid fibroblasts, leukocytes produced
LARC/MIP-3alpha only in
response to
LPS
Sun et al., Biochem Biophys Res Commun 2001
:
Treatment of the cells with mitogens [ ovine PRL, recombinant rat placental lactogen-I (PL-I) and human IL-3 ] caused a dose dependent increase in the expression of PAL31 mRNA in the PRL dependent cell line Nb2, and
IL-3 dependent cell line
BaF3
von Gise et al., Mol Cell Biol 2001
:
Additionally, we also could extend these findings to the
IL-3 dependent pro-B-cell line
BaF3 , suggesting that recruitment of MEK is a common mechanism for survival signaling by activated Raf
Delaney et al., J Neuropathol Exp Neurol 2001
(Diabetic Neuropathies) :
High glucose induces caspase cleavage in apoptotic SCs -- an effect that is blocked by
bok-asp-fmk (BAF) , a
caspase inhibitor
Zaidi et al., J Neuropathol Exp Neurol 2001
:
Cell death was inhibited by 3-methyladenine, an inhibitor of autophagic vacuole formation, but not by
Boc-Asp-FMK (BAF) , a broad
caspase inhibitor
Goetz et al., Cancer Res 2001
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
To determine whether Bcr-Abl and growth factors can affect the p53/Mdm2 pathway, we studied the expression of Mdm2 in the
IL-3 dependent pre-B cell line
BaF3 and its bcr-abl transfected derivative BaF3p185 after IL-3 deprivation or treatment with the c-Abl tyrosine kinase inhibitor STI571
Andreasson et al., Cancer Genet Cytogenet 2001
(Cell Transformation, Neoplastic...) :
To investigate the influence of ETV6/CBFA2 on cellular transformation, the fusion gene was cloned into a murine ecotropic retroviral vector and transduced into
IL-3 dependent
Ba/F3 and 32Dcl.3 and IL-7 dependent IxN/2b murine hematopoietic cell lines
Plo et al., Oncogene 2001
:
In Ba/F3-wt and in Ba/F3-Kit cells, daunorubicin stimulated within 8-15 min neutral sphingomyelinase and ceramide production but not in
SCF stimulated
Ba/F3-Kit or in Ba/F3-KitDelta27 whereas all Ba/F3 cells were equally sensitive to exogenous cell-permeant C6-ceramide
Xu et al., Biochem Biophys Res Commun 2001
:
Using
IL-2 dependent cell line
BAF/BO3beta , we found that this -130EBS element can form a specific complex with nuclear protein, which contained a novel ETS transcription factor
Long et al., Apoptosis 2002
:
The level of phosphorylated
p53 was increased as a
result of
BAF or STAU-treatment
Lee et al., J Cell Sci 2001
(Muscular Dystrophy, Emery-Dreifuss) :
We show that
emerin binds directly to barrier-to-autointegration factor (BAF), a DNA bridging protein, and that this binding to
BAF requires conserved residues in the LEM-motif of emerin
Park et al., Mol Cell Biol 2002
(Cell Transformation, Neoplastic) :
Using deletion mutants of BAF53, we show that
BAF53 is
critical for
c-Myc oncogenic activity
Dierov et al., Blood 2002
(Second Messenger Systems) :
TEL/PDGF beta R transforms
interleukin-3 (IL-3) dependent
Ba/F3 and 32D cells to IL-3 independence and induces a murine myeloproliferative disease in a bone marrow transplantation model of leukemogenesis
Drachman et al., J Biol Chem 2002
:
When expressed in the
interleukin-3 dependent cell line
Ba/F3 , the chimeric receptors were appropriately expressed on the cell surface and were able to initiate tyrosine kinase activity upon exposure to TPO
Mudhasani et al., Mol Cell Biol 2002
:
Taken together, these data suggest that BRG-1 and, very likely, an
hSWI/SNF complex are
required for transcription of
MHC class II genes
Habib et al., Biochemistry 2002
:
Retroviral mediated transduction of wild-type gamma c into XSCID JT cells restored function to the IL-21R, as shown by IL-21 induced tyrosine phosphorylation of JAK1 and JAK3, and downstream
activation of
STAT5 , in JT/gamma c cells as well as
BaF3/IL-21R alpha and primary splenic B cells
Chi et al., Nature 2002
:
Reciprocal
regulation of
CD4/CD8 expression by SWI/SNF-like
BAF complexes ... Reciprocal
regulation of
CD4/CD8 expression by SWI/SNF-like
BAF complexes
Maddens et al., Blood 2002
:
Results show that, in both
Ba/F3 and 32D murine cell lines transfected with wild-type c-kit,
stem cell factor (SCF) stimulation
resulted in a significant reduction of IR-induced apoptosis and cytotoxicity, whereas DNA repair remained unaffected
Battaglioli et al., J Biol Chem 2002
:
In vivo,
BAF57 occupies the neuronal sodium channel gene ( Nav1.2 ) promoter, and targeting to this gene
requires REST
Liu et al., Mol Cell Biol 2002
:
Furthermore, we show that the ubiquitous transcription activator Sp1 interacts with the BAF complex in vivo and augments the
BAF mediated activation of the
IFITM3 promoter
Trowbridge et al., J Biol Chem 2002
:
FGF-7 did not support cell proliferation in the absence of glycosaminoglycan or with addition of heparan sulfate or chondroitin sulfate A/C but did
stimulate BaF/KGFR division in the presence of dermatan sulfate or highly sulfated low molecular weight fractions of dermatan
Paling et al., Biochem J 2002
:
We have investigated in detail the role of SHP-1 in interleukin-3 (IL-3) signal transduction by inducibly expressing wild-type ( WT ), C453S ( substrate trapping ) and R459M ( catalytically inactive ) forms of SHP-1 in the
IL-3 dependent cell line
BaF/3
Bhat et al., J Alzheimers Dis 2002
:
To determine whether these pathways interact from a signalling perspective, we compared the effects of
BAF ( a general
caspase inhibitor ), Li+ ( a GSK3beta inhibitor ) and insulin on NGF-W induced PC12 cell death ... To determine whether these pathways interact from a signalling perspective, we compared the
effects of
BAF ( a general caspase inhibitor ), Li+ ( a GSK3beta inhibitor ) and insulin on
NGF-W induced PC12 cell death ...
BAF inhibited
caspase-3 activity and delayed cell death up to 6 h after NGF-W indicating that caspase inhibition is sufficient to prevent apoptosis ...
BAF had no major effect on GSK3betaactive site phosphorylation or activity suggesting the caspase pathway does not
regulate GSK3beta activity
Holaska et al., J Biol Chem 2003
:
Although GCL alone can not explain the disease mechanism, our results strongly support gene expression models for Emery-Dreifuss muscular dystrophy by showing that emerin binds directly to a transcriptional repressor, GCL, and by suggesting that
emerin-repressor complexes might be
regulated by
BAF
Bergeron et al., Clin Exp Allergy 2003
(Asthma) :
In transient transfection experiments,
IL-4 increased promoter activity by threefold in
BAF and BNF
Gilmore et al., Virology 2003
(Cell Transformation, Neoplastic) :
We also show that infection of the
IL3 dependent mouse B cell line
BaF3 with the MSCV-v-rel vector results in expression of v-Rel, but does not convert these cells to growth factor independence
Yamamura et al., EMBO J 1992
:
We found that the expression of EPOR induced EPO dependence in
IL-3 dependent
BAF-B03 and IL-5 dependent Y16 cells but not in IL-2 dependent CTLL-2 cells, although the EPOR expressing CTLL-2 cell lines could bind and internalize EPO as efficiently as the BAF-B03 derived cell lines
Bayle et al., J Biol Chem 2004
:
SOCS6 reduced SCF induced activation of ERK1/2 and p38 but not activation of AKT or STATs in
Ba/F3 , murine embryonic fibroblast (MEF), or COS-7 cells
Kanie et al., Leukemia 2004
:
TEL-Syk fusion transformed
interleukin-3 (IL-3) dependent murine hematopoietic cell line
BaF3 to growth factor independence
Luwor et al., Oncogene 2004
(Neoplasms) :
In order to examine the signalling pathways activated by the de2-7 EGFR and its biological effects in an in vitro system, the de2-7 EGFR gene was transfected into the murine
IL-3 dependent pro-B-cell line
BaF/3
Dermott et al., Stem Cells 2004
:
Transient expression of p205 in murine
IL-3 dependent
BaF3 and 32D-C123 progenitor cell lines inhibited IL-3 induced growth and proliferation
Rodriguez-Tarduchy et al., J Immunol 1992
:
Calcium ionophores inhibit apoptosis in the
IL-3 dependent cell line
BAF3 and maintain the cells in a viable noncycling state
Suzuki et al., EMBO J 2004
:
LAP2alpha stabilizes the association of
BAF with the PIC to stimulate intermolecular integration and suppress autointegration
Wang et al., Genes Dev 2004
(Heart Defects, Congenital) :
Importantly,
BAF180 is recruited to the promoter of these target genes and
BAF180 deficiency
affects the RA response for CRABPII and RARbeta2
Ezoe et al., J Biol Chem 2005
:
A tamoxifen-inducible form of GATA-1 ( GATA-1/ERT ) showed a minor inhibitory effect on interleukin-3 (IL-3) dependent growth of an
IL-3 dependent cell line
Ba/F3
Hartmann et al., Exp Hematol 2005
:
We investigated the impact of imatinib on telomere length and telomerase activity of the
interleukin-3 (IL-3) dependent murine pro-B cell line
BaF3 and the BCR-ABL positive, IL-3 independent transfectant BaF3p185 in vitro
Lee et al., Mol Cells 2005
:
The alanine replaced
BAF53 mutants also
stimulated p53 dependent transcription, in which the SWI/SNF and
TRRAP complexes are involved
Mihara et al., Int Immunopharmacol 2005
:
Tocilizumab inhibited the proliferation of
BaF/IL-6R induced by
IL-6 , but did not inhibit the proliferation of BaF/IL-11R, BaF/OSMR, BaF/LIFR and BaF/CNTFR cells induced by their corresponding cytokines
Nichols et al., Mol Biol Cell 2006
:
Coexpression of
VRK1 and GFP-BAF greatly
diminishes the association of
BAF with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Foster et al., Oncogene 2006
:
Activation of
Akt in HeLa cells
resulted in its association with
hSWI/SNF subunits : INI1, BAF155 and BAF170, as well as actin
Jacque et al., Nature 2006
:
Barrier-to-autointegration factor (BAF) , the LEM ( LAP, emerin, MAN ) binding partner of emerin, was
required for the association of viral cDNA with
emerin and for the ability of emerin to support virus infection
Chang et al., Oncogene 1991
:
In this study, we have measured the effects of interleukin 3 (IL-3) deprivation and restimulation on c-myc promoter usage in the
IL-3 dependent pre-B cell line
Ba/F3
Yoshikawa et al., Arch Otolaryngol Head Neck Surg 2006
(Cholesteatoma, Middle Ear) :
The messenger RNA expressions of
LARC ( liver and activation regulated chemokine ), GMCSF ( granulocyte-macrophage colony stimulating factor ), epiregulin, ICAM1 ( intercellular adhesion molecule 1 ), and TGFA ( transforming growth factor alpha ) were more strongly
up-regulated by
IL-1alpha and/or IL-1beta in MECF than in SF, suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles ... The messenger RNA expressions of
LARC ( liver and activation regulated chemokine ), GMCSF ( granulocyte-macrophage colony stimulating factor ), epiregulin, ICAM1 ( intercellular adhesion molecule 1 ), and TGFA ( transforming growth factor alpha ) were more strongly
up-regulated by IL-1alpha and/or
IL-1beta in MECF than in SF, suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles
Fukunaga et al., EMBO J 1991
:
Introduction of G-CSF receptor cDNA into
IL-3 dependent murine myeloid cell line FDC-P1 and pro-B cell line
BAF-B03 , which normally do not respond to G-CSF, enabled them to proliferate in response to G-CSF
Wang et al., J Biochem 2007
:
In this study, we show that
BAF53 is
involved in the repression of p53 dependent
p21-gene transcription by interacting with p53 both in vivo and in vitro ... In this study, we show that
BAF53 is
involved in the repression of p53 dependent p21-gene transcription by interacting with
p53 both in vivo and in vitro
Furukawa et al., J Struct Biol 2007
:
This
BAF loss was not detected before drICE activation and was
inhibited by Ac-DEVD-CHO
caspase inhibitors
Cuddapah et al., FEBS Lett 2008
:
We show that the
BAF complex mediated induction of
IFITM3 is dependent on binding of the transcriptional enhancer factor 1 ( TEF-1/TEAD1 ) to the M-CAT like elements of its promoter ... TEF-1 knock-down reduced the
BAF complex mediated activation of
IFITM3 promoter
Basham et al., Nucleic Acids Res 2008
(Neoplasms) :
Subsequent gene expression profiling and RT-qPCR analyses of
IL-3 stimulated
Ba/F3-beta cells led to the identification of putative novel STAT5 target genes
Sogo et al., J Immunol Methods 2008
:
When the pairs of chimeric receptors ( V ( H ) -IL-2Rbeta and V ( L ) -IL-2Rgamma, or V ( H ) -IL-2Rgamma and V ( L ) -IL-2Rbeta ) were expressed in
IL-3 dependent pro-B cell line
Ba/F3 and IL-2 dependent T cell line CTLL-2, the cognate antigen HEL induced selective expansion of gene modified cells in the absence of IL-3 and IL-2, respectively
Yamane et al., Biosci Rep 2008
:
We have identified a series of novel non-peptide compounds that activate the
thrombopoietin dependent cell line
Ba/F3-huMPL
Shinjyo et al., Tohoku J Exp Med 2008
(MAP Kinase Signaling System) :
Here we analyzed downstream pathways of Ras in
interleukin-3 (IL-3) dependent
Baf-3 murine derived pro-B lymphocytic cells that express constitutively active Ras mutants, using signaling pathway-specific inhibitors
Lai et al., Proc Natl Acad Sci U S A 2009
:
BAF57 RNAi and
BAF57 dominant negative mutants defective in CaM binding similarly
impair the induction of
BAF target genes
Wan et al., Eur J Immunol 2009
:
The
Brg1/Brm associated factor (BAF) chromatin remodeling complex directly binds the CD4 silencer and is
essential for
CD4 repression during T-cell development, because deletion of the ATPase subunit Brg1 or a dominant negative mutant of BAF57 each impairs CD4 repression in early thymocytes
Sogo et al., Cytokine 2009
:
When the chimeras were co-expressed in
IL-3 dependent pro-B cell line
Ba/F3 and IL-2 dependent T cell line CTLL-2, gene modified cells were selectively expanded in the absence of IL-3 and IL-2, respectively, by adding fluorescein conjugated BSA ( BSA-FL ) as a cognate antigen
Furuhata et al., Biochem Biophys Res Commun 2009
:
Like JAK2V617F overexpression, constitutively active STAT5 or
STAT3 induced aberrant p27 ( Kip1 ) expression of
Ba/F3 cells ... Like JAK2V617F overexpression, constitutively active
STAT5 or STAT3
induced aberrant p27 ( Kip1 ) expression of
Ba/F3 cells
Oya et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
WINAC dependent transcriptional regulation of
vitamin D receptor was consequently impaired by this WSTF mutation, but the recovery from DNA damage mediated by WICH was not impaired
Chintagari et al., PloS one 2010
:
The dissipation of lamellar body pH gradient by
Bafilomycin A1 (Baf A1) , an
inhibitor of
V-ATPase , increased surfactant secretion
Choi et al., Mol Pharmacol 2010
(Breast Neoplasms) :
Furthermore, treatment with 3MA markedly down-regulated capsaicin induced
p38 activation and LC3 conversion, and
BaF1 completely
down-regulated ERK activation and led to LC3II accumulation ... Furthermore, treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion, and
BaF1 completely
down-regulated ERK activation and led to LC3II accumulation
Gündogdu et al., Molecular cancer 2010
:
Using the murine
IL3 dependent cell line
BaF3 we investigated the influence of RhoH protein expression levels on IL3 mediated cellular responses
Keppler et al., J Biol Chem 2010
:
We show that the mechanism of
BAF155 mediated stabilization of
BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12, an E3 ubiquitin ligase
Tao et al., Hepatology 2011
:
At the molecular level,
BAF60a activates Bmal1 and
G6Pase transcription by way of the coactivation of retinoid related orphan receptor alpha ( RORa )
Wurster et al., BMC immunology 2012
:
BAF180 binds directly to regulatory elements in the Il-10 locus but is replaced by BAF250
BAF complexes in the absence of BAF180,
resulting in increased histone acetylation and
CBP recruitment to the IL-10 locus
Maiwald et al., BMC systems biology 2012
:
Application to the JAK-STAT signaling pathway in
Epo stimulated
BaF3-EpoR cells enabled the calculation of the time dependent label half-life and transit-time of STAT species
Chandler et al., Mol Cell Biol 2013
:
Using a THBS1 promoter-reporter gene, we further show that
BAF-A directly
regulates THBS1 promoter activity in an ARID domain dependent manner
Dykhuizen et al., Nature 2013
(Medulloblastoma) :
Endogenous
BAF complexes interact directly with endogenous topoisomerase IIa ( TOP2A ) through BAF250a and are
required for the binding of
TOP2A to approximately 12,000 sites across the genome
Ascaso et al., Eur J Immunol 1994
:
The topoisomerase II inhibitor etoposide causes a more rapid onset of apoptosis in the
IL-3 dependent cell line
BAF3 , deprived of IL-3
Avalos et al., Blood 1995
:
To identify critical regions mediating growth signal transduction by hG-CSFR, deletions or site directed amino acid substitutions were introduced into the cytoplasmic domain of hG-CSFR, and the mutant cDNAs were transfected into the murine
interleukin-3 (IL-3) dependent
Ba/F3 and FDCP cell lines
Caldenhoven et al., J Biol Chem 1995
(Acute-Phase Reaction) :
Moreover, endogenous STAT3 was tyrosine phosphorylated and activated in human
IL-5 stimulated
BaF3 cells ectopically expressing the human IL-5R ( BaF3/IL5R )
van Weert et al., J Cell Biol 1995
:
Toward this purpose,
bafilomycin A1 (Baf) , a specific
inhibitor of the vacuolar
proton pump , was used to inhibit acidification of the vacuolar system
Calvo et al., Eur J Immunol 1994
:
Proliferation of the
IL-3 dependent pro-B cell line
Ba/F3 transfected with the EPOR ( Ba/F3-EPOR ) can be supported by either IL-3 or EPO
Howard et al., J Rheumatol 1993
:
To determine if
bone associated peptide factors (BAF) differentially
affect proteoglycan and hyaluronic acid ( HA ) synthesis as a result of the maturity of the animal and of the location of chondrocytes within cartilage zones
Palokangas et al., J Biol Chem 1994
:
Bafilomycin A1 ( Baf ) , a specific
inhibitor of the vacuolar-type
proton pump , inhibited the entry of Semliki Forest virus and vesicular stomatitis virus into BHK-21 cells
Kawahara et al., Mol Cell Biol 1994
:
In the present study, we examined the functional role of the IL-2R gamma cytoplasmic region in the
IL-3 dependent mouse hematopoietic cell line
BAF-B03 , which expresses the endogenous IL-2R alpha and IL-2R gamma, or its subline F7, which additionally expresses human IL-2R beta cDNA
Weiss et al., Blood 1993
:
To study these truncations, we stably transfected the
IL-3 dependent murine cell line
Ba/F3 with wild-type or mutant cDNAs
Sakamaki et al., J Biol Chem 1993
:
These chimeric receptors and normal cytokine receptors were expressed in an
IL-3 dependent murine pro-B cell line,
Ba/F3 , and an IL-2 dependent murine T cell line, CTLL2
Vigon et al., Oncogene 1993
:
A chimeric receptor containing the extracellular domain of the granulocyte colony stimulating factor ( G-CSF) receptor fused to the transmembrane and cytoplasmic domains of Mpl was able to induce G-CSF responsiveness when transfected into the
interleukin 3 (IL-3) dependent cell line
BAF/BO3
Athanasiou et al., Oncogene 1996
:
A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo)-responsive phenotype in the cell lines FDC-P2,
BaF3 and 32Dc123. Gag-Myb-Ets expression alone did not increase expression of GATA-1 or the Epo receptor(EpoR) in the
presence of
IL3 , and infected cell lines express increased GATA-1 and EpoR only when IL3 was replaced by Epo in the culture media ... A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo)-responsive phenotype in the cell lines FDC-P2,
BaF3 and 32Dc123. Gag-Myb-Ets expression alone did not
increase expression of GATA-1 or the
Epo receptor(EpoR) in the presence of IL3, and infected cell lines express increased GATA-1 and EpoR only when IL3 was replaced by Epo in the culture media ... A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo)-responsive phenotype in the cell lines FDC-P2,
BaF3 and 32Dc123. Gag-Myb-Ets expression alone did not
increase expression of
GATA-1 or the Epo receptor(EpoR) in the presence of IL3, and infected cell lines express increased GATA-1 and EpoR only when IL3 was replaced by Epo in the culture media
Heinzen et al., Infect Immun 1996
:
The presence of the vacuolar-type ( H+ ) ATPase ( V-ATPase ) within the Coxiella vacuolar membrane was demonstrated by indirect immunofluorescence, and growth of C. burnetii was inhibited by
bafilomycin A1 (Baf A) , a specific
inhibitor of the
V-ATPase
Collins et al., J Cell Sci 1996
:
DNA fragmentation in isolated nuclei from the murine
IL3 dependent bone marrow cell line
BAF3 could be stimulated either by decreasing pH below 6.5 or by adding microM calcium at neutral pH
Deshmukh et al., J Cell Biol 1996
:
At similar concentrations,
BAF also
blocked the
NGF deprivation induced death of rat sympathetic neurons in culture
Ikushima et al., Proc Natl Acad Sci U S A 1997
:
The expression and binding activity of the Nfil3 protein ( also called E4bp4 ), but not of Hlf, Dbp, or Tef, was found to be
regulated by
IL-3 in mouse pro-B cell lines (
Baf-3 and FL5.12 )
Barber et al., Blood 1997
:
Erythropoietin (EPO) and interleukin-3 induced a dose and time dependent tyrosine phosphorylation of Cbl in both
EPO dependent
Ba/F3 and DA-3 transfectants, and the erythroid cell line HCD-57
Zhao et al., Cell 1998
:
PIP2 , which is regulated by activation stimuli, is
sufficient in vitro to target the
BAF complex to chromatin, but it has no effect on related chromatin remodeling complexes containing SNF2L or hISWI ... beta-actin and
BAF53 are
required for maximal
ATPase activity of BRG1 and are also required with BRG1 for association of the complex with chromatin/matrix
Tsujimura et al., Blood 1999
(Cell Transformation, Neoplastic...) :
When c-kitDel-Wild and c-kitDel-Tyr814 genes were introduced into a murine
interleukin-3 (IL-3) dependent cell line
Ba/F3 , KITDel-Tyr814 was constitutively phosphorylated on tyrosine and activated, whereas KITDel-Wild was not