◀ Back to MAPK3
DUSP6 — MAPK3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK3
→
DUSP6
(directlyDecreases, DUSP6 Activity, MAPK3 Activity)
Evidence: The second subfamily comprises DUSP6, DUSP7 and DUSP9. They consist of 3 exons, are cytoplasmic in their subcellular localization and preferentially recognize ERK1 and ERK2 in vitro.
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BioCarta regulation of map kinase pathways through dual specificity phosphatases:
DSP (DUSP1/DUSP9/DUSP8/DUSP2/DUSP4/DUSP6)
→
MAPK (MAPK8/MAPK14/MAPK3)
(modification, activates)
-
KEGG MAPK signaling pathway:
DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9
→
MAPK1/MAPK3
(protein-protein, inhibition)
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NCI Pathway Database ErbB1 downstream signaling:
Erk1-2-active (MAPK3/MAPK1)
→
MKP3 (DUSP6)
(modification, collaborate)
Kim et al., Biochemistry 2003*, Amit et al., Nat Genet 2007, Muda et al., J Biol Chem 1996*, Muda et al., J Biol Chem 1996*, Camps et al., Science 1998*
Evidence: assay, physical interaction
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NCI Pathway Database ErbB1 downstream signaling:
MKP3 (DUSP6)
→
Erk1-2 (MAPK3/MAPK1)
(modification, activates)
Kim et al., Biochemistry 2003*, Amit et al., Nat Genet 2007, Muda et al., J Biol Chem 1996*, Muda et al., J Biol Chem 1996*, Camps et al., Science 1998*
Evidence: assay, physical interaction
-
NCI Pathway Database FGF signaling pathway:
MKP-3 (DUSP6)
→
Erk1-2 (MAPK3/MAPK1)
(modification, inhibits)
Zhao et al., J Biol Chem 2001, Xiao et al., J Biol Chem 2002, Bryant et al., Mol Biol Cell 2005, Matsui et al., Circ Res 2011, Elfenbein et al., Science signaling 2012
Evidence: mutant phenotype, assay
-
NCI Pathway Database ErbB1 downstream signaling:
Erk1-2-active (MAPK3/MAPK1)
→
MKP3 (DUSP6)
(transcription, activates)
Amit et al., Nat Genet 2007, Muda et al., J Biol Chem 1996*
Evidence: genetic interaction
-
Reactome Reaction:
MAPK3
→
DUSP6
(reaction)
Amit et al., Nat Genet 2007
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
MAPK3
—
DUSP6
(physical association, affinity chromatography technology)
Muda et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
MAPK3
—
DUSP6
(direct interaction, pull down)
Muda et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
DUSP6
—
MAPK3
(in vitro)
Kim et al., J Biol Chem 2003, Muda et al., J Biol Chem 1998*
-
IRef Intact Interaction:
MAPK3
—
DUSP6
(physical association, coimmunoprecipitation)
Kim et al., J Biol Chem 2003
-
IRef Ophid Interaction:
MAPK3
—
DUSP6
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Reffas et al., Biochem J 2000
:
Activation of mitogen activated protein kinases ( MAPKs ), their upstream activators
MAPK kinases ( MAPKKs or MEKs ) and
induction of MKP-1 ( CL100/3CH134 ) and
MKP-3 ( Pyst1/rVH6 ) dual-specificity MAPK phosphatases ( MKPs ) were studied in the mouse embryonic stem cell line P19 during the 7 day induction of neuronal differentiation triggered by aggregation and retinoic acid
Givant-Horwitz et al., Gynecol Oncol 2004
(MAP Kinase Signaling System...) :
The objective of the present study was to investigate the expression and clinical role of
dual-specificity phosphatases ( DUSP ) ,
inhibitors of
MAPK signaling, in ovarian cancer cells at this site
Cui et al., Cancer Res 2006
(Breast Neoplasms) :
Furthermore, PD98059 increased the levels of phosphorylated c-Jun NH ( 2 ) -terminal kinase ( JNK ) in tamoxifen treated MKP3 overexpressing cells, suggesting an interaction between
MKP3 levels,
activation of ERK1/2
MAPK , and JNK signaling in human breast cancer cells
Hernández-MartÃnez et al., Development 2009
:
Inhibition of the mitogen activated protein kinase ( Mapk ) pathway prevents the survival effect of Fgf8 on interdigital cells and the accompanying
Erk1/2 phosphorylation and
induction of
Mkp3 expression
Kumabe et al., Microbiol Immunol 2010
:
Activation of
MAPK is negatively
regulated by
DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Camps et al., Science 1998
:
Catalytic
activation of the phosphatase
MKP-3 by ERK2
mitogen activated protein kinase