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IGFBP3 — MAPK7

Text-mined interactions from Literome

Lee et al., Cancer Res 2002 (Carcinoma, Non-Small-Cell Lung...) : To delineate the underlying mechanism, we examined the effect of IGFBP-3 on Akt/protein kinase B and glycogen synthase kinase-3beta, downstream mediators of the phosphatidylinositol 3-kinase pathway, and on mitogen activated protein kinase ( MAPK ), all three of which are activated by IGF mediated signaling pathways and have important roles in cell survival ... IGFBP-3 overexpression inhibited the phosphorylation of Akt and glycogen synthase kinase-3beta and the activity of MAPK
Lee et al., J Natl Cancer Inst 2004 (Carcinoma, Non-Small-Cell Lung...) : The specific effects of Ad-IGFBP 3 and SCH66336 on mitogen activated protein kinase and Akt were assessed by using adenoviral vectors that express constitutively active MEK1 or constitutively active Akt
Imamura et al., PloS one 2012 (Disease Progression...) : An increase in IGFBP-3 , mediated by depletion of FOXA1, inhibited phosphorylation of MAPK and Akt, and increased expression of the cell cycle regulators p21 and p27