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JUN — NOS3
Text-mined interactions from Literome
Kristof et al., J Biol Chem 2001
:
Mitogen activated protein kinases mediate
activator protein-1 dependent human inducible
nitric-oxide synthase promoter activation
Hoffmann et al., J Cell Physiol 2001
:
In order to study a potential
role of the redox regulated transcription factor complex
AP-1 in hypoxia induced
eNOS mRNA transcription, c-jun expression was determined and decoy experiments were performed
Kizaki et al., Biochem Biophys Res Commun 2001
:
Negative
regulation of LPS stimulated expression of inducible
nitric oxide synthase by
AP-1 in macrophage cell line J774A.1
Lee et al., Life Sci 2003
:
The regulation of inducible
nitric oxide synthase gene expression
induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells : involvement of
AP-1 and NFkappaB
Rui et al., Cardiovasc Res 2005
(Myocardial Reperfusion Injury) :
An
AP-1 `` decoy '' oligonucleotide
prevented the induction of
eNOS by EPO and reversed the beneficial effect of EPO
Cho et al., Biochim Biophys Acta 2005
:
BIC also
induces nitric oxide synthase in macrophages through
JunB/AP-1 and NF-kappaB activation
Rui et al., FASEB J 2005
(Inflammation) :
NFkappaB and
AP-1 differentially
contribute to the induction of Mn-SOD and
eNOS during the development of oxidant tolerance
Choi et al., J Biomed Sci 2005
:
Chrysoeriol potently
inhibits the induction of
nitric oxide synthase by blocking
AP-1 activation
Qian et al., Mol Cell Endocrinol 2007
:
Transcriptional
regulation of endothelial
nitric oxide synthase expression in uterine artery endothelial cells by
c-Jun/AP-1 ... We developed a c-Jun adenoviral expression system to overexpress c-Jun protein into UAEC to investigate the
effects of
c-Jun/AP-1 on
NOS3 expression ... Lastly, the pharmacological
AP-1 activator phorbol myristate acetate increased AP-1 binding, trans
activated the wild-type but not the AP-1 mutant
NOS3 promoter and dose-dependently stimulated UAEC NOS3 and c-Jun protein expression ... Hence, our data show that
c-Jun/AP-1 regulates
NOS3 transcription involving the proximal AP-1 site in the 5'-regulatory region of the sheep NOS3 gene
Hasselblatt et al., Proc Natl Acad Sci U S A 2007
(Drug-Induced Liver Injury...) :
Hepatocyte survival in acute hepatitis is due to
c-Jun/AP-1 dependent expression of inducible
nitric oxide synthase
Kumar et al., Am J Physiol Lung Cell Mol Physiol 2008
:
These data suggest a
role of decreased
AP-1 binding likely through c-Jun in the H ( 2 ) O ( 2 ) -mediated decrease in
eNOS promoter activity
Polytarchou et al., Int J Cancer 2009
(Prostatic Neoplasms) :
Inhibition of
eNOS or the downstream effector soluble guanylate cyclase ( sGC ) completely
suppressed HP-induced
AP-1 activities that lead to PTN expression and cell migration
Passos et al., Am J Pathol 2009
(Inflammation) :
MIP-1alpha ( -/- ) and CCR5 ( -/- ) mice displayed reduced astrocytosis and microgliosis in the hippocampus after Abeta ( 1-40 ) administration that was associated with decreased expression of cyclooxygenase-2 and inducible
nitric oxide synthase , as well as reduced
activation of nuclear factor-kappaB,
activator protein-1 and cyclic AMP response element binding protein
Kwon et al., Endocrinology 1996
:
Interleukin 1-induced Fos and
Jun do not
regulate inducible
nitric oxide synthase in rat islets of Langerhans and RINm5F cells
Marks-Konczalik et al., J Biol Chem 1998
:
Cytokine mediated transcriptional induction of the human inducible
nitric oxide synthase gene
requires both
activator protein 1 and nuclear factor kappaB binding sites ... The
involvement of
AP-1 and NF-kappaB transcription factors in cytokine mediated induction of human inducible
nitric oxide synthase ( hiNOS ) promoter activity was examined
Navarro-AntolĂn et al., Kidney Int Suppl 1998
:
The potential
participation of ROS and the transcription factor
AP-1 in the regulation of
eNOS gene expression is suggested