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HSP90AA1 — WT1

Text-mined interactions from Literome

Bansal et al., Blood 2010 (Leukemia, Myeloid) : RNAi mediated silencing of WT1 reduced the survival of leukemia cells and increased the sensitivity of these cells to chemotherapy and Hsp90 inhibition ... Furthermore, Hsp90 inhibitors 17-AAG [ 17- ( allylamino ) -17-demethoxygeldanamycin ] and STA-9090 significantly reduced the growth of myeloid leukemia xenografts in vivo and effectively down-regulated the expression of WT1 and its downstream target proteins, c-Myc and Bcl-2
Bansal et al., J Biol Chem 2012 (Leukemia, Myeloid, Acute) : Consistent with this, pharmacological inhibition of Hsp90 resulted in reduced WT1 and Bcl-xL expression leading to increased sensitivity of leukemia cells to TRAIL mediated apoptosis