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MSH6 — NOS2
Text-mined interactions from Literome
Galimberti et al., Biochem Biophys Res Commun 1999
:
Northern blot analysis demonstrated that
alpha-MSH [ 1-13 ] and alpha-MSH [ 11-13 ]
inhibited accumulation of
inducible nitric oxide synthase (iNOS) and TNFalpha mRNA was triggered by Abeta stimulation
Gupta et al., Kidney Int 2000
:
In contrast,
alpha-MSH ( 100 nmol/L )
had no effect on the induction of
NOS2 promoter-luciferase genes harboring deletion or mutation of the C/EBP box ... These data indicate that alpha-MSH inhibits the induction of C/EBPbeta DNA binding activity and that this effect is a major mechanism by which
alpha-MSH inhibits the transcription of the
NOS2 gene
Caruso et al., Neuroendocrinology 2004
:
alpha-MSH and HS024 ( 1 nmol/rat ) alone
had no effect on
iNOS and COX-2 expression
Colombo et al., Shock 2007
(Inflammation...) :
Bleomycin induced expression of proinflammatory and profibrotic factors ( interleukin 6, tumor necrosis factor-alpha, transforming growth factor-beta1, and inducible
nitric oxide synthase ) and chemokines ( chemokine [C-C motif] ligand 2 and chemokine [C-C motif] ligand 5 ) was likewise significantly
reduced by
NDP-alpha-MSH
Caruso et al., Endocrinology 2007
(Inflammation) :
alpha-MSH ( 5 microm )
reduced the nitric oxide production and the expression of
inducible nitric oxide synthase (iNOS) induced by bacterial lipopolysaccharide ( LPS, 1 microg/ml ) plus interferon-gamma ( IFN-gamma, 50 ng/ml ) in cultured astrocytes after 24 h. alpha-MSH also attenuated the stimulatory effect of LPS/IFN-gamma on prostaglandin E ( 2 ) release and cyclooxygenase-2 (COX-2) expression