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LEP — SREBF1
Text-mined interactions from Literome
Commerford et al., Am J Physiol Regul Integr Comp Physiol 2004
(Body Weight...) :
We conclude that 1 ) skeletal muscle SREBP-1c gene expression is regulated by nutritional status in a fashion similar to that observed in liver and adipose tissue, 2 ) physiological hyperinsulinemia is not sufficient to imitate the effects of refeeding on SREBP-1c gene expression, and 3 )
leptin suppresses refeeding effects on
SREBP-1c mRNA levels
Yan et al., Mol Med 2012
:
The aim of this study is to examine the
effect of
leptin on
SREBP-1c gene expression in HSCs in vitro and in vivo and elucidate the underlying mechanisms ... The results of the present study demonstrated that
leptin strongly
inhibited SREBP-1c expression in HSCs in vivo and in vitro ... p38 MAPK was involved in
leptin regulation of
SREBP-1c expression in cultured HSCs. Leptin induced activation of p38 MAPK led to the decreases in liver X receptor ( LXR ) -a protein level, activity and its binding to the SREBP-1c promoter, which caused the downregulation of SREBP-1c expression ... Moreover,
leptin inhibition of
SREBP-1c expression via p38 MAPK increased the expression of alpha1 ( I ) collagen in HSCs
Zhang et al., Int J Biochem Cell Biol 2013
(Liver Cirrhosis...) :
Our previous results demonstrated the inhibitory
effect of
leptin on
SREBP-1c expression in HSCs ... The present study aimed to explore the role of Stat3 pathway in leptin induced liver fibrogenesis in mouse model, focusing on examining the effect of
leptin induced Stat3 pathway on
SREBP-1c expression in HSCs in vitro and in vivo ... Results suggested that Stat3 pathway mediated the promotional role of leptin in liver fibrosis in mouse and was involved in
leptin inhibition of
SREBP-1c expression in HSCs. Leptin induced Stat3 activation was, at least partially, ERK pathway dependent in cultured HSCs and was correlated positively with ß-catenin activity and negatively with liver X receptor a expression and activity which influenced SREBP-1c expression in HSCs ... In summary, the effect of
leptin induced Stat3 pathway on
SREBP-1c expression in HSCs might contribute to the role of leptin in liver fibrosis in mouse, thus advancing understanding of the mechanisms of liver fibrogenesis associated with leptin
Zhai et al., Br J Pharmacol 2013
:
The ß-catenin pathway contributes to the
effects of
leptin on
SREBP-1c expression in rat hepatic stellate cells and liver fibrosis ... We have shown that
leptin strongly
inhibits SREBP-1c expression in rat HSCs. Hence, we aimed to clarify whether the ß-catenin pathway, the crucial negative regulator of adipocyte differentiation, mediates the effects of leptin on SREBP-1c expression in HSCs and in mouse liver fibrosis ... The leptin induced ß-catenin pathway reduced
SREBP-1c expression and activity but did not affect protein levels of key regulators controlling SREBP-1c activity, and was not
involved in
leptin inhibition of liver X receptor a ... The ß-catenin pathway contributes to
leptin regulation of
SREBP-1c expression in HSCs and leptin induced liver fibrosis in mice