Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gosset et al., Eur Respir J 1999 : Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols
Aihara et al., Respiration 2000 : We investigated the effects of NAC and AMB on secretions of IL-12 and IL-10 from human alveolar macrophages ... NAC also enhanced LPS induced IL-10 secretion, while AMB did not ... The ratio IL-12/IL-10 secretion was increased by AMB, but NAC did not affect it
Perianayagam et al., Eur J Clin Invest 2005 (Uremia) : In addition, ET-stimulated IL-10 production by cells incubated with uraemic plasma was also restored by both catalase and NAC
Xu et al., Acta Pharmacol Sin 2009 (Disease Models, Animal...) : NAC treatment also decreased the pulmonary protein content at 48 and 72 h and the lung wet/dry weight ratio at 24 and 48 h. Additionally, NAC enhanced pulmonary production of TNF-alpha and IL-10 at 24 h and 48 h
Abdel Baki et al., PloS one 2010 (Brain Injuries) : When dosed 3 hours before injury, MINO plus NAC as single drugs had no effect on interleukin-1 formation ; together they synergistically lowered interleukin-1 levels
Galicia-Moreno et al., Eur J Gastroenterol Hepatol 2012 (Cholestasis...) : NAC was effectively significant in preventing TGF-ß and IL-6 expression and further augmented the IL-10 expression
Ehsani et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2012 : To evaluate the role of prophylactic ibuprofen and N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha ( TNF- a ), interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions