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RAC1 — SOS1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RAC1 → SOS1 (increases)
  Evidence: A dominant negative form of SOS, carrying a series of point mutations inactivating the DH domain suppresed the activation of Rac in HUVECs plated on fibronectin in complete SFM.
• BioCarta ras signaling pathway: 0030676 (VAV1/SOS1) → RAC1 (modification, activates)
• NCI Pathway Database ErbB1 downstream signaling: RAC1/GDP complex (RAC1) → SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) (modification, collaborate)
  Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database ErbB1 downstream signaling: SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) → RAC1/GTP complex (RAC1) (modification, activates) Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: RAC1/GDP complex (RAC1) → SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) (modification, collaborate)
  Scita et al., Nature 1999, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) → RAC1/GTP complex (RAC1) (modification, activates) Scita et al., Nature 1999, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) (modification, collaborate)
  Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004, Khanday et al., J Cell Biol 2006*
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) → RAC1/GTP complex (RAC1) (modification, activates) Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004, Khanday et al., J Cell Biol 2006*
  Evidence: assay
• Reactome Reaction: SOS1 → RAC1 (indirect_complex) Tybulewicz et al., Immunol Rev 2003, Bos et al., Cell 2007
• Reactome Reaction: SOS1 → RAC1 (reaction) Abe et al., J Biol Chem 2000, Zeng et al., Mol Cell Biol 2000, Chong et al., J Biol Chem 2001, Harrington et al., J Neurosci 2002, Parrini et al., Mol Cell 2002, Tybulewicz et al., Immunol Rev 2003, Bos et al., Cell 2007

Text-mined interactions from Literome

Innocenti et al., J Cell Biol 2002 : Thus, the involvement of Sos-1 at two distinct and differentially regulated steps of the signaling cascade allows for coordinated activation of Ras and Rac and different duration of their signaling within the cell
Furuta et al., Oncogene 2002 : Sos1 expression induced membrane ruffling, a downstream target for Rac1 , but LC3 expression inhibited this biological effect of Sos1 ... These findings suggest that LC3 interacts with Sos1 and thereby negatively regulates the Sos1 dependent Rac1 activation leading to membrane ruffling
Sini et al., Nat Cell Biol 2004 : Abl dependent tyrosine phosphorylation of Sos-1 mediates growth-factor induced Rac activation
Silver et al., Genesis 2004 : These alleles provide new tools for future investigations of SOS mediated activation of both RAS and RAC and how these dual roles are coordinated and coregulated during development
Hwang et al., J Cell Biol 2011 : CIIA promoted the SOS1-Rac1 interaction and inhibited the SOS1-Ras interaction ... Furthermore, CIIA promoted the formation of an SOS1-EPS8 complex and SOS1 mediated Rac1 activation , whereas it inhibited SOS1 mediated activation of Ras
Kovacevic et al., EMBO J 2012 : NOSTRIN forms a complex with the GTPase Rac1 and its exchange factor Sos1 and overexpression of NOSTRIN in cells induces Rac1 activation