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MTOR — RPS6
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mieulet et al., Am J Physiol Cell Physiol 2007 (Muscular Atrophy) :
The phosphorylation of
ribosomal protein S6 (rpS6) , eukaryotic initiation factor-4B (eIF4B), and eukaryotic elongation factor-2 ( eEF2 ) is predominantly
regulated by
mTOR in muscle cells
Li et al., J Immunol 2011 (HIV Infections...) :
Targeted gene silencing of MyD88 ( short hairpin RNA ) and
mTOR ( RNA interference ) inhibition
resulted in TLR-4 mediated 70-kDa
ribosomal protein S6 kinase activation and enhanced TNF-a release, whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages
Galbaugh et al., BMC cell biology 2006 :
But lower levels of PI-3-K and
mTOR inhibitors were
required to block insulin induced phosphorylation of
RPS6 than EGF induced phosphorylation, and insulin induced phosphorylation of elF4E and 4E-BP1 was not completely mTOR dependent suggesting some diversity of signaling for EGF and insulin
Villanueva et al., Endocrinology 2009 :
To determine the mechanisms by which leptin modulates mTORC1 in specific hypothalamic neurons, we immunohistochemically assessed the
mTORC1 dependent phosphorylation of
ribosomal protein S6 (pS6)
Kimball et al., J Biol Chem 1999 :
Leucine regulates translation of specific mRNAs in L6 myoblasts through
mTOR mediated changes in availability of eIF4E and phosphorylation of
ribosomal protein S6
Tuhácková et al., Int J Mol Med 2004 :
IL2 dependent phosphorylation of
40S ribosomal protein S6 is
controlled by
PI-3K/mTOR signalling in CTLL2 cells ... IL2 dependent phosphorylation of 40S
ribosomal protein S6 is
controlled by
PI-3K/mTOR signalling in CTLL2 cells
Bonito-Oliva et al., Neuropharmacology 2013 :
Haloperidol promotes
mTORC1 dependent phosphorylation of
ribosomal protein S6 via dopamine- and cAMP regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1
Tamura et al., ISRN pharmacology 2013 :
Rapamycin, an inhibitor of mTOR complex 1, reduced the level of HIF-1 a and blocked phosphorylation of
ribosomal protein S6 kinase 1 (S6K) , a transcriptional
regulator of
mTOR , demonstrating that hypoxia activates mTOR/S6K/HIF-1 a signaling in CCA
Shao et al., Cancer Res 2004 (Cell Transformation, Neoplastic...) :
p70
ribosomal protein S6 kinase activity was induced by K-Ras in a PI3K- and
mTOR dependent manner
Gundermann et al., J Appl Physiol 2012 (Hyperemia) :
BFR exercise
increased the phosphorylation of mTOR, S6 kinase 1,
ribosomal protein S6 , ERK1/2, and Mnk1 interacting kinase 1 ( P < 0.05 ) with no changes in
mTORC1 signaling in the SNP trial ( P > 0.05 )
Knaup et al., Mol Cancer Res 2009 :
However, certain proteins are believed to be preferentially translated during hypoxia via 5 ' terminal oligopyrimidine tract mechanisms with controversial discussion about the involvement of the
mTOR dependent
ribosomal protein S6 (rpS6)