UCSC Mouse Gene Sorter

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UCSC Mouse Gene Sorter

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#	Name	VisiGene	BLASTP E-Value	Genome Position	Description
1	Jak1	185936	0	chr4 101,208,824	Mus musculus Janus kinase 1 (Jak1), transcript variant 1, mRNA. (from RefSeq NM_146145)
2	Tyk2	188491	0	chr9 21,117,651	Mus musculus tyrosine kinase 2 (Tyk2), transcript variant 1, mRNA. (from RefSeq NM_001205312)
3	Jak2	73902	0	chr19 29,282,454	Mus musculus Janus kinase 2 (Jak2), transcript variant 1, mRNA. (from RefSeq NM_008413)
4	Jak3	177383	0	chr8 71,683,435	Mus musculus Janus kinase 3 (Jak3), transcript variant 1, mRNA. (from RefSeq NM_010589)
5	Tnk2	59876	1e-41	chr16 32,672,372	Tnk2 (from geneSymbol)
6	Fgfr4	156208	2e-41	chr13 55,160,699	Mus musculus fibroblast growth factor receptor 4 (Fgfr4), mRNA. (from RefSeq NM_008011)
7	Frk	176406	8e-41	chr10 34,547,338	Mus musculus fyn-related kinase (Frk), transcript variant 2, mRNA. (from RefSeq NM_010237)
8	Erbb4	146772	1e-40	chr1 68,569,971	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactaction. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. (from UniProt Q61527)
9	Fgfr1	149532	1e-39	chr8 25,547,238	Mus musculus fibroblast growth factor receptor 1 (Fgfr1), transcript variant 1, mRNA. (from RefSeq NM_010206)
10	Zap70	188632	2e-39	chr1 36,772,308	Mus musculus zeta-chain (TCR) associated protein kinase (Zap70), transcript variant 1, mRNA. (from RefSeq NM_009539)
11	Fgfr2	156702	1e-38	chr7 130,214,357	Mus musculus fibroblast growth factor receptor 2 (Fgfr2), transcript variant 2, mRNA. (from RefSeq NM_201601)
12	Ntrk2	145144	1e-38	chr13 58,970,833	Mus musculus neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2), transcript variant 1, mRNA. (from RefSeq NM_001025074)
13	Ntrk3	145154	4e-38	chr7 78,377,183	Mus musculus neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), transcript variant 1, mRNA. (from RefSeq NM_008746)
14	Ptk2b	187598	8e-38	chr14 66,217,157	Mus musculus PTK2 protein tyrosine kinase 2 beta (Ptk2b), transcript variant 3, mRNA. (from RefSeq NM_172498)
15	Hck	176948	2e-37	chr2 153,129,921	Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). (from UniProt P08103)
16	Ptk2	162693	2e-37	chr15 73,314,146	Mus musculus PTK2 protein tyrosine kinase 2 (Ptk2), transcript variant 1, mRNA. (from RefSeq NM_007982)
17	Abl1	162377	3e-37	chr2 31,782,085	Mus musculus c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), transcript variant 2, mRNA. (from RefSeq NM_009594)
18	Srms	181231	4e-37	chr2 181,209,373	Mus musculus src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srms), mRNA. (from RefSeq NM_011481)
19	Ntrk1	145144	4e-37	chr3 87,786,703	Mus musculus neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA. (from RefSeq NM_001033124)
20	Mst1r	178985	3e-37	chr9 107,913,628	Mus musculus macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (Mst1r), transcript variant 1, mRNA. (from RefSeq NM_009074)
21	Abl2	173185	1e-36	chr1 156,600,882	Mus musculus v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) (Abl2), transcript variant 2, mRNA. (from RefSeq NM_009595)
22	Egfr	150898	3e-36	chr11 16,835,184	Mus musculus epidermal growth factor receptor (Egfr), transcript variant 1, mRNA. (from RefSeq NM_207655)
23	Lyn	178559	3e-36	chr4 3,734,869	Mus musculus LYN proto-oncogene, Src family tyrosine kinase (Lyn), transcript variant 2, mRNA. (from RefSeq NM_010747)
24	Met	200	5e-36	chr6 17,518,890	Mus musculus met proto-oncogene (Met), mRNA. (from RefSeq NM_008591)
25	Csk	137419	5e-36	chr9 57,640,272	Mus musculus c-src tyrosine kinase (Csk), transcript variant 2, mRNA. (from RefSeq NM_001304761)
26	Fgfr3	156202	5e-36	chr5 33,729,396	Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 2, mRNA. (from RefSeq NM_001163215)
27	Ddr1	163534	7e-36	chr17 35,693,083	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. (from UniProt Q03146)
28	Epha2	146735	8e-36	chr4 141,315,312	Mus musculus Eph receptor A2 (Epha2), mRNA. (from RefSeq NM_010139)
29	Ddr2	175626	3e-35	chr1 170,041,434	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. (from UniProt Q62371)
30	Ret	154800	1e-34	chr6 118,174,439	Mus musculus ret proto-oncogene (Ret), transcript variant 2, mRNA. (from RefSeq NM_009050)
31	Musk	187050	6e-35	chr4 58,330,132	Mus musculus muscle, skeletal, receptor tyrosine kinase (Musk), transcript variant 4, mRNA. (from RefSeq NM_010944)
32	Erbb2	146526	6e-35	chr11 98,425,093	Mus musculus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA. (from RefSeq NM_001003817)
33	Syk	181371	1e-34	chr13 52,615,982	Mus musculus spleen tyrosine kinase (Syk), transcript variant 2, mRNA. (from RefSeq NM_001198977)
34	Epha7	145849	2e-34	chr4 28,890,315	Mus musculus Eph receptor A7 (Epha7), transcript variant 1, mRNA. (from RefSeq NM_010141)
35	Epha8	176105	2e-34	chr4 136,943,117	Mus musculus Eph receptor A8 (Epha8), mRNA. (from RefSeq NM_007939)
36	Ryk	180577	1e-34	chr9 102,871,229	Mus musculus receptor-like tyrosine kinase (Ryk), transcript variant 1, mRNA. (from RefSeq NM_013649)
37	Epha3	150309	1e-34	chr16 63,703,846	Mus musculus Eph receptor A3 (Epha3), transcript variant 1, mRNA. (from RefSeq NM_010140)
38	Matk	178667	3e-34	chr10 81,260,143	Mus musculus megakaryocyte-associated tyrosine kinase (Matk), transcript variant 2, mRNA. (from RefSeq NM_001285853)
39	Epha5	151826	2e-34	chr5 84,237,298	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. (from UniProt E9PUQ0)
40	Erbb3	142081	2e-33	chr10 128,578,587	Mus musculus erb-b2 receptor tyrosine kinase 3 (Erbb3), mRNA. (from RefSeq NM_010153)
41	Epha4	155041	1e-33	chr1 77,441,136	Mus musculus Eph receptor A4 (Epha4), mRNA. (from RefSeq NM_007936)
42	Lck	177612	3e-33	chr4 129,560,995	Mus musculus lymphocyte protein tyrosine kinase (Lck), transcript variant 3, mRNA. (from RefSeq NM_001162433)
43	Tnk1	182010	4e-33	chr11 69,854,867	Mus musculus tyrosine kinase, non-receptor, 1 (Tnk1), mRNA. (from RefSeq NM_031880)
44	Src	163380	2e-33	chr2 157,445,139	Src (from geneSymbol)
45	Fes	185435	3e-33	chr7 80,382,852	Mus musculus feline sarcoma oncogene (Fes), mRNA. (from RefSeq NM_010194)
46	Tek	144036	5e-33	chr4 94,807,119	Mus musculus TEK receptor tyrosine kinase (Tek), transcript variant 1, mRNA. (from RefSeq NM_013690)
47	Ptk7	180116	6e-33	chr17 46,596,987	Mus musculus PTK7 protein tyrosine kinase 7 (Ptk7), mRNA. (from RefSeq NM_175168)
48	Ephb2	151832	5e-33	chr4 136,741,763	Mus musculus Eph receptor B2 (Ephb2), transcript variant 2, mRNA. (from RefSeq NM_010142)
49	Epha1	185278	5e-33	chr6 42,365,877	Mus musculus Eph receptor A1 (Epha1), mRNA. (from RefSeq NM_023580)
50	Fer	176291	1e-32	chr17 64,017,742	Mus musculus fer (fms/fps related) protein kinase (Fer), transcript variant 1, mRNA. (from RefSeq NM_001037997)