IKMC Genes Track Settings
 
International Knockout Mouse Consortium Genes   (All Genes and Gene Predictions tracks)

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Data last updated at UCSC: 2012-05-23

Description

This track shows genes targeted by International Knockout Mouse Consortium (IKMC), a collaboration to generate a public resource of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. Gene targets are color-coded by status:

  • Green: Reagent(s) Available
  • Yellow: In Progress
  • Blue: Not Started/On Hold
  • Black: Withdrawn/Problematic

The KnockOut Mouse Project Data Coordination Center (KOMP DCC) is the central database resource for coordinating mouse gene targeting within IKMC and provides web-based query and display tools for IKMC data. In addition, the KOMP DCC website provides a tool for the scientific community to nominate genes of interest to be knocked out by the KOMP initiative.

IKMC members include

KOMP includes two production centers: CSD, a collaborative team at the Children's Hospital Oakland Research Institute (CHORI), the Wellcome Trust Sanger Institute and the University of California at Davis School of Veterinary Medicine, and a team at the VelociGene division of Regeneron Pharmaceuticals, Inc. EUCOMM includes 9 participating institutions. NorCOMM includes several participating institutions.

Items displayed as a solid box represent the gene regions targeted by the Regeneron gene knockout strategy. In most cases Regeneron alleles will be complete null alleles that delete the entire protein coding sequence of the target gene.

Items displayed as lines connecting short boxes represent the targeting vector construct strategy used by EuCOMM, NorCOMM, and CSD. This strategy relies on the identification of a "critical" exon common to all transcript variants that, when deleted, creates a frame-shift mutation. The short boxes in the middle of an item show the vector features that surround the critical exon.

Methods

Using complementary targeting strategies, the IKMC centers design and create targeting vectors, mutant ES cell lines and, to some extent, mutant mice, embryos or sperm. Materials are distributed to the research community.

The KOMP Repository archives, maintains, and distributes IKMC products. Researchers can order products and get product information from the Repository. Researchers can also express interest in products that are still in the pipeline. They will then receive email notification as soon as KOMP generated products are available for distribution.

The process for ordering EUCOMM materials can be found here.

The process for ordering TIGM materials can be found here.

Information on NorCOMM products and services can be found here.

Credits

Thanks to the International Knockout Mouse Consortium, and Carol Bult in particular, for providing these data.

References

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT et al. The knockout mouse project. Nat Genet. 2004 Sep;36(9):921-4. PMID: 15340423; PMC: PMC2716027

Collins FS, Finnell RH, Rossant J, Wurst W. A new partner for the international knockout mouse consortium. Cell. 2007 Apr 20;129(2):235. PMID: 17448981

International Mouse Knockout Consortium, Collins FS, Rossant J, Wurst W. A mouse for all reasons. Cell. 2007 Jan 12;128(1):9-13. PMID: 17218247