This super-track combines related tracks of ChIP-chip data generated by
the ENCODE group at the Sanger Institute.
ChIP-chip, also known as genome-wide location analysis, is a technique for
isolation and identification of DNA sequences bound by specific proteins in
cells, including histones. Histone methylation and acetylation serves as a
stable genomic imprint
that regulates gene expression and other epigenetic
phenomena. These histones are found in transcriptionally active domains
These tracks contain ChIP-chip data for H3 and H4 histones
in multiple cell lines, including HeLa (cervical carcinoma),
GM06990 (lymphoblastoid), K562 (myeloid leukemia), and
HFL-1 (embryonic lung fibroblast).
Experiments were conducted with
antibodies to histones with different post-translational modification marks.
Data are displayed as signals as well as hits and peak
centers identified by hidden Markov model (HMM) analysis.
The data were generated by the
ENCODE investigators at the
Wellcome Trust Sanger
Institute, Hinxton, UK.
Ian Dunham and
The HMM analysis was performed at the EBI by
Raw data may be downloaded from the Sanger Institute website at