Sanger ChIP-chip Tracks
 
Sanger ChIP-chip (histones H3,H4 ab in GM06990, K562, HeLa, HFL-1, MOLT4, and PTR8 cells) tracks   (All Pilot ENCODE Chromatin Immunoprecipitation tracks)

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Sanger ChIP  Sanger ChIP-chip (histones H3,H4 ab in GM06990, K562, HeLa, and other cells)  Source data version: ENCODE June & Oct 2005 Freezes, Aug 2006 & Jan 2007 data
Sanger ChIP Hits  Sanger ChIP-chip Hits and Peak Centers  Source data version: ENCODE Oct 2005 Freeze

Overview

This super-track combines related tracks of ChIP-chip data generated by the ENCODE group at the Sanger Institute. ChIP-chip, also known as genome-wide location analysis, is a technique for isolation and identification of DNA sequences bound by specific proteins in cells, including histones. Histone methylation and acetylation serves as a stable genomic imprint that regulates gene expression and other epigenetic phenomena. These histones are found in transcriptionally active domains called euchromatin.

These tracks contain ChIP-chip data for H3 and H4 histones in multiple cell lines, including HeLa (cervical carcinoma), GM06990 (lymphoblastoid), K562 (myeloid leukemia), and HFL-1 (embryonic lung fibroblast). Experiments were conducted with antibodies to histones with different post-translational modification marks. Data are displayed as signals as well as hits and peak centers identified by hidden Markov model (HMM) analysis.

Credits

The data were generated by the ENCODE investigators at the Wellcome Trust Sanger Institute, Hinxton, UK. Contacts: Ian Dunham and Christoph Koch.

The HMM analysis was performed at the EBI by Paul Flicek.

Raw data may be downloaded from the Sanger Institute website at ftp://ftp.sanger.ac.uk/pub/encode.