This super-track combines related tracks of ChIP-chip data generated by
the Ludwig Institute/UCSD ENCODE group.
ChIP-chip, also known as genome-wide location analysis, is a technique for
isolation and identification of DNA sequences bound by specific proteins in
cells, including histones. Histone methylation and acetylation serves as a
stable genomic imprint
that regulates gene expression and other epigenetic
phenomena. These histones are found in transcriptionally active domains
These tracks contain ChIP-chip data for transcription initiation
complex (such as Pol2 and TAF1) and H3, H4 histones in multiple
cell lines, including HeLa (cervical carcinoma), IMR90 (human fibroblast),
and HCT116 (colon epithelial carcinoma), with some experiments
including interferon-gamma induction.
The data for this track were generated at the
Ren Lab, Ludwig
Institute for Cancer Research at UC San Diego.
Kim TH, Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM,
Glass CK, Rosenfeld MG, Myers RM, Ren B.
Direct isolation and identification of promoters in the human
Genome Res. 2005 Jun;15(6):830-9.
Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B.
A global transcriptional regulatory role for c-Myc in Burkitt's
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8164-9.
Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J,
Schreiber J, Hannett N, Kanin E et al.
Genome-wide location and function
of DNA-associated proteins.
Science. 2000 Dec 22;290(5500):2306-9.
Kim TH, Barrera LO, Zheng M, Qu C, Singer MA, Richmond TA, Wu Y, Green RD,
A high-resolution map of active promoters in the human genome.
Nature. 2005 Aug 11;436(7052):876-80.