This super-track combines related tracks of DNA
replication data from the University of Virginia.
DNA replication is carefully coordinated, both across the genome and with
respect to development. Earlier replication in S-phase is broadly correlated
with gene density and transcriptional activity.
These tracks contain temporal profiling of DNA replication and
origin of DNA replication in multiple cell lines, such as
HeLa cells (cervix carcinoma). Replication timing was measured by
analyzing Brd-U-labeled fractions from synchronized cells on tiling arrays.
Data generation and analysis for this track were performed by the
DNA replication group in the
at the University of Virginia: Neerja Karnani, Christopher Taylor,
Hakkyun Kim, Louis Lim, Ankit Malhotra, Gabe Robins and Anindya Dutta.
Neerja Karnani and Christopher Taylor prepared the data for presentation in
the UCSC Genome Browser.
Giacca M, Pelizon C, Falaschi A.
Mapping replication origins by quantifying relative abundance
of nascent DNA strands using competitive polymerase chain reaction.
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Mesner LD, Crawford EL, Hamlin JL.
Isolating apparently pure libraries of replication origins
from complex genomes. Mol Cell. 2006 Mar 3;21(5):719-26.
Jeon Y, Bekiranov S, Karnani N, Kapranov P, Ghosh S, MacAlpine D, Lee C,
Hwang DS, Gingeras TR, Dutta A.
Temporal profile of replication of human chromosomes.
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6419-24.