This super-track combines related tracks of DNaseI
sensitivity data from University of Washington (UW).
DNaseI has long been used to map general chromatin accessibility and
the DNaseI "hyperaccessibility" or "hypersensitivity"
that is a universal feature of active cis-regulatory sequences.
The use of this method has led to the discovery of functional
regulatory elements that
include enhancers, insulators, promotors, locus control regions and novel
elements. DNaseI hypersensitivity signifies chromatin accessibility following
binding of trans-acting factors in place of a canonical nucleosome,
and is a universal feature of active cis-regulatory sequences in vivo.
These tracks contain DNaseI analysis of multiple cell lines using the
QCP method or DNaseI-chip.
Data generation, analysis, and validation were performed by the following
members of the ENCODE group at UW in Seattle.
Genetics: Patrick Navas, Man Yu, Hua Cao, Brent Johnson, Ericka
Johnson, Tristan Frum, and George Stamatoyannopoulos.
UW Genome Sciences:
Michael O. Dorschner, Richard Humbert, Peter J. Sabo, Scott Kuehn, Robert
Thurman, Anthony Shafer, Jeff Goldy, Molly Weaver, Andrew Haydock, Kristin
Lee, Fidencio Neri, Richard Sandstrom, Shane Neff, Brendan Henry, Michael
Hawrylycz, Janelle Kawamoto, Paul Tittel, Jim Wallace, William S. Noble, and
John A. Stamatoyannopoulos.
Dorschner MO, Hawrylycz M, Humbert R, Wallace JC, Shafer A,
Kawamoto J, Mack J, Hall R, Goldy J, Sabo PJ et al.
High-throughput localization of functional elements by
quantitative chromatin profiling.
Nat Methods. 2004 Dec;1(3):219-25.
Sabo PJ, Kuehn MS, Thurman R, Johnson BE, Johnson EM, Cao H, Yu M,
Rosenzweig E, Goldy J, Haydock A et al.
Genome-scale mapping of DNase I sensitivity in vivo using tiling
Nat Methods. 2006 Jul;3(7):511-8.