This track shows a 3-SNP moving average of
p(1-p) where p is the major allele frequency
(i.e. half of the expected heterozygosity)
on seven continents,
from SNPs genotyped in 53 populations worldwide by the
Genome Diversity Project in collaboration with the
du Polymorphisme Humain (HGDP-CEPH).
This track and several others are available from the
HGDP Selection Browser.
Samples collected by the HGDP-CEPH from 1,043 individuals from around the
world were genotyped for 657,000 SNPs at
The 53 populations were divided into seven continental groups: Africa,
Middle East, Europe, South Asia, East Asia, Oceania and the Americas.
Allele frequencies were used to calculate p(1-p)
for each SNP, and then a
3-SNP average was computed for each SNP and its two neighboring SNPs.
The associated analysis tracks HGDP FST, HGP iHS, and HGDP XP-EHH
(Pickrell et al.) did not make use of all African populations, but
instead used only the Bantu populations because a more closely related
group was desired for comparison with other continental groups.
For this track, separate subtracks show the expected heterozygosity
of all African populations and of only Bantu populations.
Thanks to the HGDP-CEPH and Joe Pickrell in the
lab at the University of Chicago for providing these data.
Pickrell JK, Coop G, Novembre J, Kudaravalli S, Li J, Absher D,
Srinivasan BS, Barsh GS, Myers RM, Feldman MW, Pritchard JK.
Signals of recent positive selection in a worldwide sample of
human populations. Genome Res. 2009 May;19(5):826-37.
Li JZ, Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S,
Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM.
Worldwide human relationships inferred from genome-wide
patterns of variation. Science. 2008 Feb 22;319(5866):1100-4.
Cann HM, de Toma C, Cazes L, Legrand MF, Morel V, Piouffre L, Bodmer
J, Bodmer WF, Bonne-Tamir B, Cambon-Thomsen A et al.
A human genome diversity cell line panel.
Science. 2002 Apr 12;296(5566):261-2.